HPGDS-IN-1

hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。

信号通路 >> 免疫及炎症 >> PGE合成酶

研究领域 >> 炎症/免疫

[1]. Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.

[2]. Hahn Chang S. Method for treating macular degeneration using syk multikinase inhibitor, an hPGDS inhibitor and a DP antagonist. From PCT Int. Appl. (2010), WO 2010080563 A2 20100715.

[3]. Weiberth Franz J, et al. Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester. From Organic Process Research & Development (2012), 16(12), 19

甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮 | Zomepirac钠盐 | 氟比洛芬 | 利马前列素 | 2-(9-氯-1H-菲酚[9,10-d]咪唑-2-基)-1,3-苯二甲腈 | 盐酸苄达明 | 碱式水杨酸铋 | HPGDS抑制剂1 | 普拉洛芬 | 舒洛芬 | PGS-IN-1