UNC0321

• 常用名: UNC0321
• 英文名: UNC0321
• CAS号: 1238673-32-9
• 分子量: 515.691
• 密度: 1.2±0.1 g/cm3
• 沸点: 664.7±65.0 °C at 760 mmHg
• 分子式: C₂₇H₄₅N₇O₃
• 熔点: N/A
• 闪点: 355.8±34.3 °C

UNC0321用途

UNC0321是高亲和性G9a抑制剂,Ki为63 pM。UNC0321是第一个皮摩尔级G9a抑制剂,也是迄今为止G9a抑制剂中活性最强的。

UNC0321名称

• 中文名: 7-[2-[2-(二甲基氨基)乙氧基]乙氧基]-2-(六氢-4-甲基-1H-1,4-二氮杂卓-1-基)-6-甲氧基-N-(1-甲基-4-哌啶基)-4-喹唑啉胺
• 英文名: 7-{2-[2-(Dimethylamino)ethoxy]ethoxy}-6-methoxy-2-(4-methyl-1,4-d iazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine

UNC0321生物活性

• 描述: UNC0321是高亲和性G9a抑制剂,Ki为63 pM。UNC0321是第一个皮摩尔级G9a抑制剂,也是迄今为止G9a抑制剂中活性最强的。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.

  [2]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

UNC0321物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 664.7±65.0 °C at 760 mmHg
• 分子式: C₂₇H₄₅N₇O₃
• 分子量: 515.691
• 闪点: 355.8±34.3 °C
• 精确质量: 515.358398
• PSA: 81.69000
• LogP: 0.36
• InChIKey: AULLUGALUBVBDD-UHFFFAOYSA-N
• SMILES: COc1cc2c(NC3CCN(C)CC3)nc(N3CCCN(C)CC3)nc2cc1OCCOCCN(C)C
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.582
• 储存条件: 2-8℃

UNC0321靶点实验

查看更多实验

实验名称：qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1):... 来源：NCGC 靶标：thioredoxin reductase [Rattus norvegicus] External Id：TRXR101

实验名称：Activity at methyl transferase activity G9a by enzyme coupled S-adenocylehomocystein ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL1217455

实验名称：qHTS for Inhibitors of Polymerase Iota 来源：NCGC 靶标：DNA polymerase iota [Homo sapiens] External Id：PolI100

实验名称：Inhibition of methyl transferase activity of G9a assessed as inhibition of H3K9 methy... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL1217453

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

共21条，当前第1页，共3页

1

2

3

UNC0321英文别名

• 7-(2-(2-(Dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
• 7-{2-[2-(Dimethylamino)ethoxy]ethoxy}-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
• UNC0321
• TFA salt