GR79236

更新时间：2024-01-08 11:48:36

GR79236结构式	常用名	GR79236	英文名	GR 79236
	CAS号	124555-18-6	分子量	351.35800
	密度	1.89g/cm3	沸点	728.3ºC at 760mmHg
	分子式	C₁₅H₂₁N₅O₅	熔点	N/A
	MSDS	中文版美版	闪点	394.3ºC
	符号	GHS07	信号词	Warning

GR79236用途

GR79236是一种高度有效的选择性腺苷A1受体激动剂 (Ki=3.1 nm), 具有镇痛和抗炎作用。

中文名	GR79236
英文名	(2R,3R,4S,5R)-2-[6-[[(1S,2S)-2-hydroxycyclopentyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
英文别名	更多

描述	GR79236是一种高度有效的选择性腺苷A1受体激动剂 (Ki=3.1 nm), 具有镇痛和抗炎作用。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体研究领域 >> 炎症/免疫
参考文献	[1]. Sneyd JR, et al. Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction. Br J Anaesth. 2007 May;98(5):672-676. [2]. Arulmani U, et al. Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs. Cephalalgia. 2005 Nov;25(11):1082-90.

描述

GR79236是一种高度有效的选择性腺苷A1受体激动剂 (Ki=3.1 nm), 具有镇痛和抗炎作用。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 炎症/免疫

参考文献

[1]. Sneyd JR, et al. Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction. Br J Anaesth. 2007 May;98(5):672-676.

[2]. Arulmani U, et al. Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs. Cephalalgia. 2005 Nov;25(11):1082-90.

密度	1.89g/cm3
沸点	728.3ºC at 760mmHg
分子式	C₁₅H₂₁N₅O₅
分子量	351.35800
闪点	394.3ºC
精确质量	351.15400
PSA	145.78000
外观性状	白色固体
蒸汽压	0mmHg at 25°C
折射率	1.846
储存条件	2-8℃

符号	GHS07
信号词	Warning
危害声明	H302-H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲)	Xn
风险声明 (欧洲)	R22
安全声明 (欧洲)	26-36
危险品运输编码	NONH for all modes of transport

Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction.

Br. J. Anaesth. 98(5) , 672-6, (2007)

Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain.Seventy-nine patients ...

Does a selective adenosine A(1) receptor agonist protect against exercise induced ischaemia in patients with coronary artery disease?

Heart 87(2) , 115-20, (2002)

The "warm up" effect in angina may represent ischaemic preconditioning, which is mediated by adenosine A(1) receptors in most models.To investigate the effect of a selective A(1) agonist, GR79236 (Gla...

Improvement of ketoacidosis in the diabetic rat after the administration of the oral antilipolytic agent GR 79236.

Clin. Sci. 86(5) , 593-8, (1994)

1. We assessed the effect of a novel oral antilipolytic agent, N-[(1S, trans)-2-hydroxycyclopentyl]adenosine (GR 79236), in experimental diabetic ketoacidosis. Ketotic rats were gavaged with GR 79236 ...

HMS3268O08

N-[(1S (trans)-2-Hydroxycyclopentyl]adenosine

GR79236