GSK-5498A

• 常用名: GSK-5498A
• 英文名: GSK-5498A
• CAS号: 1253186-49-0
• 分子量: 399.290
• 密度: 1.4±0.1 g/cm3
• 沸点: 403.3±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₁F₆N₃O
• 熔点: N/A
• 闪点: 197.7±28.7 °C

GSK-5498A用途

GSK-5498A 是CARC离子通道选择性小分子抑制剂(IC50 = 1_mu_M)；抑制肥大细胞介质释放和T细胞促炎性细胞因子的释放。

GSK-5498A名称

• 中文名: GSK-5498A
• 英文名: 2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide

GSK-5498A生物活性

• 描述: GSK-5498A 是CARC离子通道选择性小分子抑制剂(IC50 = 1_mu_M)；抑制肥大细胞介质释放和T细胞促炎性细胞因子的释放。
• 相关类别:
  信号通路 >> 跨膜转运 >> CRAC频道
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Rice LV, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.

GSK-5498A物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 403.3±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₁F₆N₃O
• 分子量: 399.290
• 闪点: 197.7±28.7 °C
• 精确质量: 399.080627
• PSA: 46.92000
• LogP: 2.62
• InChIKey: AUBGZAJDHUHMAE-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccn(Cc2c(F)cccc2C(F)(F)F)n1)c1c(F)cccc1F
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.552
• 储存条件: 2-8℃

GSK-5498A靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce... 来源：NCGC External Id：s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay 来源：NCGC External Id：NTMT1-p-MTaseGlo

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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GSK-5498A英文别名

• 2,6-Difluoro-N-{1-[2-fluoro-6-(trifluoromethyl)benzyl]-1H-pyrazol-3-yl}benzamide
• gsk-5498a