洋椿苦素

• 常用名: 洋椿苦素
• 英文名: Cedrelone
• CAS号: 1254-85-9
• 分子量: 422.51
• 密度: 1.3±0.1 g/cm3
• 沸点: 584.2±50.0 °C at 760 mmHg
• 分子式: C₂₆H₃₀O₅
• 熔点: N/A
• 闪点: 307.1±30.1 °C

洋椿苦素用途

雪松酮(Cedrelone)是一种柠檬酸,是一种类吩嗪生物合成结构域的蛋白质(PBLD)激活剂。雪松酮诱导癌症细胞凋亡,具有抗肿瘤作用[1]。

洋椿苦素名称

• 中文名: 洋椿苦素
• 英文名: ac1mj135

洋椿苦素生物活性

• 描述: 雪松酮(Cedrelone)是一种柠檬酸,是一种类吩嗪生物合成结构域的蛋白质(PBLD)激活剂。雪松酮诱导癌症细胞凋亡,具有抗肿瘤作用[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Jiansong Wu, et al. Novel compound cedrelone inhibits hepatocellular carcinoma progression via PBLD and Ras/Rap1. Exp Ther Med. 2019 Dec;18(6):4209-4220.

洋椿苦素物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 584.2±50.0 °C at 760 mmHg
• 分子式: C₂₆H₃₀O₅
• 分子量: 422.51
• 闪点: 307.1±30.1 °C
• 精确质量: 422.209320
• PSA: 80.04000
• LogP: 3.85
• InChIKey: OQMUOVSEPOBWMK-UHFFFAOYSA-N
• SMILES: CC1(C)C(=O)C=CC2(C)C1=C(O)C(=O)C1(C)C2CCC2(C)C(c3ccoc3)CC3OC321
• 外观性状: 粉末
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.618
• 储存条件: 2-8℃，干燥，密闭

洋椿苦素安全信息

• 危害码 (欧洲): Xi

洋椿苦素靶点实验

查看更多实验

实验名称：Antifeedant activity against larvae of Spodoptera litura in castor leaves relative to... 来源：ChEMBL 靶标：Spodoptera litura External Id：CHEMBL3069882

实验名称：Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimo... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1 External Id：CHEMBL3039488

实验名称：Antifungal activity against Puccinia arachidis in ground nut assessed as rust pustule... 来源：ChEMBL 靶标：Puccinia arachidis External Id：CHEMBL3058453

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Antifungal activity against Puccinia arachidis in ground nut assessed as rust pustule... 来源：ChEMBL 靶标：Puccinia arachidis External Id：CHEMBL3058454

实验名称：Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichi... 来源：ChEMBL 靶标：Co-chaperonin GroES External Id：CHEMBL4392938

实验名称：Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherich... 来源：ChEMBL 靶标：Co-chaperonin GroES External Id：CHEMBL4392939

实验名称：Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction... 来源：ChEMBL 靶标：DNA repair protein RAD52 homolog External Id：CHEMBL4482621

实验名称：Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3 External Id：CHEMBL3039491

实验名称：Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening 来源：11827 靶标：Phosphogluconate dehydrogenase External Id：6PGD_Inhibitor_Screening_2015_09

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洋椿苦素英文别名

• (13α,14β,15β,17α)-17-(3-Furyl)-6-hydroxy-4,4,8-trimethyl-14,15-epoxyandrosta-1,5-diene-3,7-dione
• (1S,2aR,3aR,3bR,9aR,9bR,11aS)-1-(Furan-3-yl)-5-hydroxy-3b,6,6,9a,11a-pentamethyl-2,2a,6,9a,9b,10,11,11a-octahydronaphtho[1',2':6,7]indeno[1,7a-b]oxirene-4,7(1H,3bH)-dione
• 14,15,21,23-diepoxy-6-hydroxy-4,4,8-trimethyl-24-nor-chola-1,5,20,22-tetraene-3,7-dione
• Dihydrocedrelon
• (13α,14β,15β,17α)-17-(furan-3-yl)-6-hydroxy-4,4,8-trimethyl-14,15-epoxyandrosta-1,5-diene-3,7-dione
• 14,15,21,23-Diepoxy-6-hydroxy-4,4,8-trimethyl-24-nor-chola-1,5,20,22-tetraen-3,7-dion