p38α inhibitor 4

• 常用名: p38α inhibitor 4
• 英文名: p38α inhibitor 4
• CAS号: 1262406-08-5
• 分子量: 347.22
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₇F₆N₃O
• 熔点: N/A
• 闪点: N/A

p38α inhibitor 4用途

p38α抑制剂4(化合物10)是一种选择性变构p38α的抑制剂,其IC50值为1.2μM。p38α抑制剂4对p38β、p38γ和p38δ无活性[1]。

p38α inhibitor 4名称

• 英文名: 4-(Trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H- pyrazolo[3,4-b]pyridin-6-one

p38α inhibitor 4生物活性

• 描述: p38α抑制剂4(化合物10)是一种选择性变构p38α的抑制剂,其IC50值为1.2μM。p38α抑制剂4对p38β、p38γ和p38δ无活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
• 靶点实验:

  p38α:1.2 μM (IC50)

• 参考文献:

  [1]. ACS Chem. Biol., Article ASAPDOI: 10.1021/cb1002619Publication Date (Web): November 23, 2010

  [2]. Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.

p38α inhibitor 4物理化学性质

• 分子式: C₁₄H₇F₆N₃O
• 分子量: 347.22
• 精确质量: 347.04900
• PSA: 61.80000
• LogP: 4.36810
• InChIKey: YEINPIKXEQEWSU-UHFFFAOYSA-N
• SMILES: O=c1cc(C(F)(F)F)c2c(-c3cccc(C(F)(F)F)c3)[nH]nc2[nH]1

p38α inhibitor 4靶点实验

查看更多实验

实验名称：Activation of GPX4 (unknown origin) at 500 uM relative to control 来源：ChEMBL 靶标：Phospholipid hydroperoxide glutathione peroxidase External Id：CHEMBL4406954

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：Activation of GPX4 (unknown origin) at 20 uM relative to control 来源：ChEMBL 靶标：Phospholipid hydroperoxide glutathione peroxidase External Id：CHEMBL4406955

实验名称：Activation of GPX4 (unknown origin) at 61 uM by cell-based assay relative to control 来源：ChEMBL 靶标：Phospholipid hydroperoxide glutathione peroxidase External Id：CHEMBL4406956

共4条，当前第1页，共1页

1