巴西芬净

• 常用名: 巴西芬净
• 英文名: Basifungin
• CAS号: 127785-64-2
• 分子量: 1101.42000
• 密度: 1.19g/cm3
• 沸点: 1229.1ºC at 760 mmHg
• 分子式: C₆₀H₉₂N₈O₁₁
• 熔点: N/A
• 闪点: 697.1ºC

巴西芬净用途

奥雷巴西汀A(Basifungin)是一种环二肽,是一种抗真菌抗生素。Aureobasidin A(Basifungin)A是肌醇磷酸神经酰胺合酶AUR1[1][2]的抑制剂。

巴西芬净名称

• 中文名: 巴西芬净
• 英文名: aureobasidin A

巴西芬净生物活性

• 描述: 奥雷巴西汀A(Basifungin)是一种环二肽,是一种抗真菌抗生素。Aureobasidin A(Basifungin)A是肌醇磷酸神经酰胺合酶AUR1[1][2]的抑制剂。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 炎症/免疫
• 体外研究: Aureobasidin A通过神经酰胺中毒和必需肌醇磷酸神经酰胺的剥夺阻止酵母细胞的生长[2]。
• 参考文献:

  [1]. K Ikai, et al. Structure of aureobasidin A. J Antibiot (Tokyo). 1991 Sep;44(9):925-33.

  [2]. Vanessa Cerantola, et al. Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol. 2009 Mar;71(6):1523-37.

  [3]. K Kino, et al. Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins. FEBS Lett. 1996 Dec 9;399(1-2):29-32.

巴西芬净物理化学性质

• 密度: 1.19g/cm3
• 沸点: 1229.1ºC at 760 mmHg
• 分子式: C₆₀H₉₂N₈O₁₁
• 分子量: 1101.42000
• 闪点: 697.1ºC
• 精确质量: 1100.69000
• PSA: 245.85000
• LogP: 4.88900
• InChIKey: RLMLFADXHJLPSQ-UHFFFAOYSA-N
• SMILES: CCC(C)C1NC(=O)C2CCCN2C(=O)C(Cc2ccccc2)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(C(C)C)N(C)C(=O)C(C(C)CC)OC(=O)C(C(C)(C)O)N(C)C(=O)C(CC(C)C)NC(=O)C(C(C)C)N(C)C1=O
• 外观性状: 固体
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.574
• 储存条件: 2-8°C，密封，干燥

巴西芬净靶点实验

查看更多实验

实验名称：Antifungal activity against Candida krusei ATCC 6258 (Y-7179) assessed as reduction i... 来源：ChEMBL 靶标：Pichia kudriavzevii External Id：CHEMBL5390674

实验名称：Antifungal activity against Candida albicans SC5314 assessed as reduction in fungal g... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL5390673

实验名称：Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in fung... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL5390672

实验名称：Antifungal activity against Candida parapsilosis ATCC 22019 (Y-12969) assessed as red... 来源：ChEMBL 靶标：Candida parapsilosis External Id：CHEMBL5390671

实验名称：Cytotoxicity against human HEK293 cells assessed as cell survival at 1 times MIC incu... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4818273

实验名称：Antifungal activity against Fusarium solani 243G2 assessed as reduction in fungal gro... 来源：ChEMBL 靶标：Fusarium solani External Id：CHEMBL5390707

实验名称：Noncompetitive inhibition of aureobasidin A-resistant Saccharomyces cerevisiae inosit... 来源：ChEMBL 靶标：Inositol phosphorylceramide synthase catalytic subunit AUR1 External Id：CHEMBL1634542

实验名称：Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability at 2... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4818274

实验名称：Antifungal activity against Mucor circinelloides 235C7 assessed as reduction in funga... 来源：ChEMBL 靶标：Mucor circinelloides External Id：CHEMBL5390706

实验名称：Inhibition of Saccharomyces cerevisiae SJ21R inositol phosphorylceramide synthase 来源：ChEMBL 靶标：Inositol phosphorylceramide synthase catalytic subunit AUR1 External Id：CHEMBL1634543

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巴西芬净英文别名

• aurantoside B