西那司特结构式
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常用名 | 西那司特 | 英文名 | Cinalukast |
|---|---|---|---|---|
| CAS号 | 128312-51-6 | 分子量 | 412.54500 | |
| 密度 | 1.258g/cm3 | 沸点 | N/A | |
| 分子式 | C23H28N2O3S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
西那司特用途Ro 24-5913(Cinalukast)是一种口服活性和有效的LTD4拮抗剂,IC50值为6.4nM。Ro 24-5913可用于哮喘研究[1]。 |
| 中文名 | 西那司特 |
|---|---|
| 英文名 | cinalukast |
| 英文别名 | 更多 |
| 描述 | Ro 24-5913(Cinalukast)是一种口服活性和有效的LTD4拮抗剂,IC50值为6.4nM。Ro 24-5913可用于哮喘研究[1]。 |
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| 相关类别 | |
| 靶点 |
IC50: 6.4 nM (LTD4)[1] |
| 体外研究 | Ro 24-5913与[3H]LTD4竞争其在豚鼠肺膜中的结合位点,IC50值为6.4nM[1]。Ro 24-5913显示了对LTD4诱导的收缩的有效拮抗剂效力,pKB值为9.3[1]。 |
| 体内研究 | Ro 24-5913(静脉注射10 mg/kg和口服100 mg/kg；一次)抑制LTD4诱导的豚鼠支气管收缩,静脉注射和口服LD50分别为0.13和0.12 mg/kg[1]。动物模型：豚鼠[1]剂量：10 mg/kg给药：口服灌胃；结果：抑制LTD4诱导的豚鼠支气管收缩和抗原诱导的支气管收缩。 |
| 密度 | 1.258g/cm3 |
|---|---|
| 分子式 | C23H28N2O3S |
| 分子量 | 412.54500 |
| 精确质量 | 412.18200 |
| PSA | 107.53000 |
| LogP | 5.87360 |
| 折射率 | 1.655 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 危险品运输编码 | NONH for all modes of transport |
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Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death.
J. Physiol. Pharmacol. 60(3) , 135-43, (2009) Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Eryptosis is triggered by in... |
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Prolonged protection against exercise-induced bronchoconstriction by the leukotriene D4-receptor antagonist cinalukast.
J. Allergy Clin. Immunol. 99(2) , 210-5, (1997) The degree and duration of protection against exercise-induced bronchoconstriction afforded by three doses of a specific leukotriene D4 receptor antagonist, cinalukast, were assessed after an initial ... |
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Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma.
Biochem. Pharmacol. 44(7) , 1411-5, (1992) We have identified and characterized two different subclasses of binding site for the novel peptido-leukotriene (LT) antagonist, [3H]ICI 198,615, in membranes from human lung parenchyma using a recept... |
| Cinalukast |
| 4-[3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]anilino]-2,2-diethyl-4-oxobutanoic acid |
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