尿石素D

• 常用名: 尿石素D
• 英文名: Urolithin D
• CAS号: 131086-98-1
• 分子量: 260.20
• 密度: 1.8±0.1 g/cm3
• 沸点: 634.1±55.0 °C at 760 mmHg
• 分子式: C₁₃H₈O₆
• 熔点: N/A
• 闪点: 253.0±25.0 °C

尿石素D用途

尿锂蛋白D是EphA受体的竞争性和可逆性拮抗剂。尿锂蛋白D表现出类内选择性[1]。

尿石素D名称

• 中文名: 尿石素D
• 英文名: 3,4,8,9-tetrahydroxybenzo[c]chromen-6-one

尿石素D生物活性

• 描述: 尿锂蛋白D是EphA受体的竞争性和可逆性拮抗剂。尿锂蛋白D表现出类内选择性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> 艾弗林受体
• 参考文献:

  [1]. Giorgio C, et al. The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells. Mol Nutr Food Res. 2015 Nov;59(11):2155-67.

尿石素D物理化学性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 634.1±55.0 °C at 760 mmHg
• 分子式: C₁₃H₈O₆
• 分子量: 260.20
• 闪点: 253.0±25.0 °C
• 精确质量: 260.032074
• PSA: 111.13000
• LogP: 1.07
• InChIKey: NEZDQSKPNPRYAW-UHFFFAOYSA-N
• SMILES: O=c1oc2c(O)c(O)ccc2c2cc(O)c(O)cc12
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.801

尿石素D靶点实验

查看更多实验

实验名称：Effect on ppGalNAcT2 expression level in human HT-29 cells at 40 uM incubated for 48 ... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4386665

实验名称：Effect on ppGalNAcT4 expression level in human HT-29 cells at 40 uM incubated for 48 ... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4386666

实验名称：Antimigratory activity in human HT-29 cells at 40 uM incubated for 48 hrs by crystal ... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4386657

实验名称：Antimigratory activity in human HCT116 cells at 40 uM incubated for 48 hrs by crystal... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4386658

实验名称：Inhibition of DNA gyrase supercoiling in Escherichia coli. 来源：ChEMBL 靶标：DNA gyrase subunit B External Id：CHEMBL658170

实验名称：Antimigratory activity in human SW480 cells at 40 uM incubated for 48 hrs by crystal ... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4386659

实验名称：Antimigratory activity in human RKO cells at 40 uM incubated for 48 hrs by crystal vi... 来源：ChEMBL 靶标：RKO External Id：CHEMBL4386660

实验名称：Anti-invasive activity in human HCT116 cells at 40 uM incubated for 48 hrs by crystal... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4386661

实验名称：Reduction in PDPN protein expression in human HT-29 cells at 40 uM for 48 hrs by West... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4386662

实验名称：Inhibition of ppGalNAcT2 in human HT-29 cells assessed as reduction in PDPN O-GalNAc ... 来源：ChEMBL 靶标：Polypeptide N-acetylgalactosaminyltransferase 2 External Id：CHEMBL4386663

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尿石素D英文别名

• 3,4,8,9-Tetrahydroxy-6H-benzo[c]chromen-6-one
• 3,4,8,9-Tetrahydroxybenzo[c]chromen-6-one
• urolithin D