Pyr10

• 常用名: Pyr10
• 英文名: Pyr10
• CAS号: 1315323-00-2
• 分子量: 449.370
• 密度: 1.5±0.1 g/cm3
• 沸点: 470.1±55.0 °C at 760 mmHg
• 分子式: C₁₈H₁₃F₆N₃O₂S
• 熔点: N/A
• 闪点: 238.1±31.5 °C
• 符号: GHS07
• 信号词: Warning

Pyr10用途

Pyr10是一种新型TRPC3选择性抑制剂, 作用于转染YFP-TRPC3的HEK293细胞, 抑制ROCE, IC50为0.72 uM。

Pyr10名称

• 中文名: Pyr10
• 英文名: Pyr10

Pyr10生物活性

• 描述: Pyr10是一种新型TRPC3选择性抑制剂, 作用于转染YFP-TRPC3的HEK293细胞, 抑制ROCE, IC50为0.72 uM。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 其他
• 参考文献:

  [1]. Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-1722.

  [2]. Obermayer D, et al. Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides. J Org Chem. 2011 Aug 19;76(16):6657-6669.

Pyr10物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 470.1±55.0 °C at 760 mmHg
• 分子式: C₁₈H₁₃F₆N₃O₂S
• 分子量: 449.370
• 闪点: 238.1±31.5 °C
• 精确质量: 449.063263
• LogP: 5.16
• InChIKey: CVALMMCIOLXHDM-UHFFFAOYSA-N
• SMILES: Cc1ccc(S(=O)(=O)Nc2ccc(-n3nc(C(F)(F)F)cc3C(F)(F)F)cc2)cc1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.556
• 储存条件: 2-8℃

Pyr10安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P301 + P312 + P330-P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport

Pyr10靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGF... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL5303712

实验名称：Incucyte cell viability with human fibroblast 来源：ChEMBL 靶标：Fibroblast External Id：CHEMBL4725213

实验名称：Incucyte cell viability with HEK293T 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL4725212

实验名称：Incucyte cell viability with U2OS 来源：ChEMBL 靶标：U2OS External Id：CHEMBL4725214

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibition of MBD4 by quantifying inhibition of MBD4-mediated cleavage and dissociati... 来源：ChEMBL 靶标：Methyl-CpG-binding domain protein 4 External Id：CHEMBL5665444

实验名称：Inhibition of MPG by quantifying inhibition of MPG-mediated cleavage and dissociation... 来源：ChEMBL 靶标：DNA-3-methyladenine glycosylase External Id：CHEMBL5665445

实验名称：Inhibition of MUTYH by quantifying inhibition of MUTYH-mediated cleavage and dissocia... 来源：ChEMBL 靶标：Adenine DNA glycosylase External Id：CHEMBL5665446

实验名称：Inhibition of NEIL1 by quantifying inhibition of NEIL1-mediated cleavage and dissocia... 来源：ChEMBL 靶标：Endonuclease 8-like 1 External Id：CHEMBL5665447

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Pyr10英文别名

• N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methylbenzenesulfonamide