10-Vinyl-19-norpregn-4-ene-3,20-dione

• 常用名: 10-Vinyl-19-norpregn-4-ene-3,20-dione
• 英文名: 10-Vinyl-19-norpregn-4-ene-3,20-dione
• CAS号: 13258-85-0
• 分子量: 326.47200
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₃₀O₂
• 熔点: N/A
• 闪点: N/A

10-Vinyl-19-norpregn-4-ene-3,20-dione用途

Org OD 02-0 (10-Ethenyl-19-norprogesterone) 是一种膜孕酮受体 α (mPRα) 特异性激动剂 (IC50: 33.9 nM)。Org OD 02-0 激活 MAPK 活性。Org OD 02-0 抑制垂体催乳素 (PRL) 分泌。

10-Vinyl-19-norpregn-4-ene-3,20-dione名称

• 英文名: Org OD 02-0

10-Vinyl-19-norpregn-4-ene-3,20-dione生物活性

• 描述: Org OD 02-0 (10-Ethenyl-19-norprogesterone) 是一种膜孕酮受体 α (mPRα) 特异性激动剂 (IC50: 33.9 nM)。Org OD 02-0 激活 MAPK 活性。Org OD 02-0 抑制垂体催乳素 (PRL) 分泌。
• 相关类别:
  信号通路 >> 其他 >> 孕激素受体
  研究领域 >> 内分泌
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
• 靶点实验:

  33.9 nM (mPRα)[1]

• 参考文献:

  [1]. Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75(4-5):314-22.

  [2]. Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30(9):e12614.

10-Vinyl-19-norpregn-4-ene-3,20-dione物理化学性质

• 分子式: C₂₂H₃₀O₂
• 分子量: 326.47200
• 精确质量: 326.22500
• PSA: 34.14000
• LogP: 4.88960
• InChIKey: VFNRBPBEOXXVPX-GCOBIYGJSA-N
• SMILES: C=CC12CCC(=O)C=C1CCC1C2CCC2(C)C(C(C)=O)CCC12

10-Vinyl-19-norpregn-4-ene-3,20-dione英文别名

• 19-Methylen-progestron
• (8S,9S,10S,13S,14S,17S)-17-Acetyl-13-methyl-10-vinyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
• 10-ethenyl-19-norprogesterone