脱水穿心莲内酯

• 常用名: 脱水穿心莲内酯
• 英文名: Dehydroandrographolide
• CAS号: 134418-28-3
• 分子量: 332.43
• 密度: 1.2±0.1 g/cm3
• 沸点: 512.8±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₈O₄
• 熔点: N/A
• 闪点: 178.3±23.6 °C

脱水穿心莲内酯用途

脱水穿心莲内酯(Dehydroandrographolide)是从中草药穿心莲提取的天然化合物，具有抗感染活性。

脱水穿心莲内酯名称

• 中文名: 脱水穿心莲内酯
• 英文名: Dehydroandrographolide
• 中文别名: 穿心莲丁素 | 穿心莲总内酯干浸膏,穿心莲丁素 | 川贝母

脱水穿心莲内酯生物活性

• 描述: 脱水穿心莲内酯(Dehydroandrographolide)是从中草药穿心莲提取的天然化合物,具有抗感染活性。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  天然产物 >> 萜类化合物和糖苷
  研究领域 >> 感染
• 参考文献:

  [1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6.

  [2]. Chao WW, et al. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010 May 13;5:17.

  [3]. Basak A, et al. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J. 1999 Feb 15;338 ( Pt 1):107-13.

  [4]. Zhu T, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.

  [5]. Chen H, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9.

脱水穿心莲内酯物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 512.8±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₈O₄
• 分子量: 332.43
• 闪点: 178.3±23.6 °C
• PSA: 86.99000
• LogP: 2.97
• InChIKey: YIIRVUDGRKEWBV-LHHJGKSTSA-N
• SMILES: C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CC=C1C=COC1=O
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.584
• 储存条件: 室温

脱水穿心莲内酯安全信息

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• RTECS号: LU3490300

脱水穿心莲内酯英文别名

• (3E)-4-Hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl]ethylidene}furan-2(3H)-one
• Dehydroanddrographolide
• 2(3H)-Furanone,3-[2-[(1S,4aS,5R,6R,8aS)-decahydro
• DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
• (3E)-4-Hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}-2(3H)-furanone
• Dehydroandrographoline
• 6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-,(3E)
• ANDROGRAPHOLIDE,DEHYDRO
• 14-Deoxy-11-dehydroandrographolide
• Dehydrographkide