ONO-4059模拟

• 常用名: ONO-4059模拟
• 英文名: ONO-4059 (analog)
• CAS号: 1351635-67-0
• 分子量: 456.496
• 密度: 1.4±0.1 g/cm3
• 沸点: 714.0±70.0 °C at 760 mmHg
• 分子式: C₂₅H₂₄N₆O₃
• 熔点: N/A
• 闪点: 385.6±35.7 °C

ONO-4059模拟用途

这个产品是ONO-4059的类似物，ONO-405是一种高效的选择性Btk抑制剂, IC50值为sub-nM级。

ONO-4059模拟名称

• 中文名: 6-氨基-7,9-二氢-9-[(3S)-1-(1-氧代-2-丙烯-1-基)-3-哌啶基]-7-(4-苯氧基苯基)-8H-嘌呤-8-酮
• 英文名: 6-Amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one

ONO-4059模拟生物活性

• 描述: 这个产品是ONO-4059的类似物,ONO-405是一种高效的选择性Btk抑制剂, IC50值为sub-nM级。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> BTK
  研究领域 >> 癌症
• 参考文献:

  [1]. Simon Rule,A Phase I Study Of The Oral Btk Inhibitor ONO-4059 In Patients With Relapsed/Refractory B-Cell Lymphoma. November 15, 2013; Blood: 122 (21)

  [2]. Toshio Yoshizawa, et al. Development of a Bruton's Tyrosine Kinase (Btk) Inhibitor, ONO-4059: Efficacy in a Collagen Induced Arthritis (CIA) Model Indicates Potential Treatment for Rheumatoid Arthritis (RA). Washington, DC November 9-14, 2012.

  [3]. Yamamoto, et al. Preparation of purinone derivatives as selective Btk inhibitors. From PCT Int. Appl. (2011), WO 2011152351 A1 20111208.

ONO-4059模拟物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 714.0±70.0 °C at 760 mmHg
• 分子式: C₂₅H₂₄N₆O₃
• 分子量: 456.496
• 闪点: 385.6±35.7 °C
• 精确质量: 456.190979
• LogP: 1.82
• InChIKey: KSUDUUBCXJUFRL-SFHVURJKSA-N
• SMILES: C=CC(=O)N1CCCC(n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.677
• 储存条件: -20℃

ONO-4059模拟安全信息

• 危害码 (欧洲): N

ONO-4059模拟靶点实验

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ONO-4059模拟英文别名

• 9-[(3S)-1-Acryloyl-3-piperidinyl]-6-amino-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
• ONO-4059
• ONO4059 analog
• ONO-4059 (analog)