IDH-C227

• 常用名: IDH-C227
• 英文名: IDH-C227
• CAS号: 1355324-14-9
• 分子量: 498.59100
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₁FN₄O₂
• 熔点: N/A
• 闪点: N/A

IDH-C227用途

IDH-C227是一种有效的选择性IDH1R132H抑制剂。IDH-C227具有抗癌作用[1]。

IDH-C227名称

• 英文名: 2-((4-cyanophenyl)amino)-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide

IDH-C227生物活性

• 描述: IDH-C227是一种有效的选择性IDH1R132H抑制剂。IDH-C227具有抗癌作用[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 异柠檬酸脱氢酶(IDH)
• 体外研究: IDH-C227显示出抗癌效果,对HT1080和U87MG细胞的IC50值分别为<0.1μM和0.25μM[1]。
• 参考文献:

  [1]. Hanumantha Rao Madala, et al. Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies. Cancers (Basel). 2018 Feb 11;10(2):49.

IDH-C227物理化学性质

• 分子式: C₃₀H₃₁FN₄O₂
• 分子量: 498.59100
• 精确质量: 498.24300
• PSA: 85.23000
• LogP: 6.10498
• InChIKey: AATMNHPDEZNXEK-UHFFFAOYSA-N
• SMILES: Cc1ccccc1C(C(=O)NC1CCCCC1)N(C(=O)CNc1ccc(C#N)cc1)c1cccc(F)c1

IDH-C227靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

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