BRD4770

• 常用名: BRD4770
• 英文名: BRD 4770
• CAS号: 1374601-40-7
• 分子量: 413.468
• 密度: 1.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₅H₂₃N₃O₃
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

BRD4770用途

BRD4770是新型组蛋白甲基转移酶G9a(EHMT2)抑制剂,在PANC-1细胞中EC50值为5uM(三甲基化H3K9)。

BRD4770名称

• 中文名: BRD4770
• 英文名: Methyl 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate

BRD4770生物活性

• 描述: BRD4770是新型组蛋白甲基转移酶G9a(EHMT2)抑制剂,在PANC-1细胞中EC50值为5uM(三甲基化H3K9)。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Yuan Y, et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.

BRD4770物理化学性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₂₅H₂₃N₃O₃
• 分子量: 413.468
• 精确质量: 413.173950
• LogP: 5.49
• InChIKey: UCGWYCMPZXDHNR-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc2c(c1)nc(NC(=O)c1ccccc1)n2CCCc1ccccc1
• 外观性状: white to beige
• 折射率: 1.625
• 储存条件: 2-8°C
• 水溶解性: DMSO: soluble5mg/mL, clear (warmed)

BRD4770安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: NONH for all modes of transport

BRD4770靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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BRD4770英文别名

• 1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-, methyl ester
• Methyl 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate
• BRD4770