双辛基马来酰亚胺III

• 常用名: 双辛基马来酰亚胺III
• 英文名: Bisindolylmaleimide III
• CAS号: 137592-43-9
• 分子量: 384.43
• 密度: 1.4±0.1 g/cm3
• 沸点: 708.7±60.0 °C at 760 mmHg
• 分子式: C₂₃H₂₀N₄O₂
• 熔点: N/A
• 闪点: 382.4±32.9 °C

双辛基马来酰亚胺III用途

双吲哚甲酰亚胺III是一种有效且选择性的蛋白激酶C(PKC)抑制剂。在激活PKCα或核糖体S6蛋白激酶1后,双吲哚甲酰亚胺III选择性地与这些激酶相互作用[1]。

双辛基马来酰亚胺III名称

• 中文名: 双辛基马来酰亚胺III
• 英文名: Bisindolylmaleimide III

双辛基马来酰亚胺III生物活性

• 描述: 双吲哚甲酰亚胺III是一种有效且选择性的蛋白激酶C(PKC)抑制剂。在激活PKCα或核糖体S6蛋白激酶1后,双吲哚甲酰亚胺III选择性地与这些激酶相互作用[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> PKC
  研究领域 >> 癌症
  信号通路 >> TGF-beta/Smad 信号通路 >> PKC
• 靶点实验:

  PKCα

• 参考文献:

  [1]. Brehmer D, et, al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500.

  [2]. Saito Y, et, al. Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells. Mol Cell Endocrinol. 1999 Jun 25;152(1-2):65-72.

双辛基马来酰亚胺III物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 708.7±60.0 °C at 760 mmHg
• 分子式: C₂₃H₂₀N₄O₂
• 分子量: 384.43
• 闪点: 382.4±32.9 °C
• 精确质量: 384.158630
• PSA: 92.91000
• LogP: 3.15
• InChIKey: APYXQTXFRIDSGE-UHFFFAOYSA-N
• SMILES: NCCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.739

双辛基马来酰亚胺III靶点实验

查看更多实验

实验名称：Inhibition of His-tagged human SAPK2b/p38b2 expressed in Escherichia coli at 1 uM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 11 External Id：CHEMBL1249570

实验名称：Inhibition of His-tagged human SAPK2a/p38 expressed in Escherichia coli at 1 uM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 14 External Id：CHEMBL1249569

实验名称：Inhibition of His-tagged human JNK1a1/SAPK1c expressed in Escherichia coli at 1 uM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 8 External Id：CHEMBL1249568

实验名称：Inhibition of His-tagged human MAPK2/ERK2 expressed in Escherichia coli at 1 uM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 1 External Id：CHEMBL1249567

实验名称：Inhibition of rabbit MKK1 expressed in Escherichia coli at 1 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL1249566

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Inhibition of His-tagged human PKCalpha expressed in Escherichia coli at 1 uM 来源：ChEMBL 靶标：Protein kinase C alpha type External Id：CHEMBL1249578

实验名称：Inhibition of bovine heart PKA at 1 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL1249577

实验名称：Inhibition of His-tagged human PRAK expressed in Sf9 cells at 1 uM 来源：ChEMBL 靶标：MAP kinase-activated protein kinase 5 External Id：CHEMBL1249576

实验名称：Inhibition of His-tagged human MSK1 expressed in Sf9 cells at 1 uM 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL1249575

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双辛基马来酰亚胺III英文别名

• 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione