Bisindolylmaleimide III

Modify Date: 2024-01-16 13:41:41

Bisindolylmaleimide III Structure
Bisindolylmaleimide III structure
Common Name Bisindolylmaleimide III
CAS Number 137592-43-9 Molecular Weight 384.43
Density 1.4±0.1 g/cm3 Boiling Point 708.7±60.0 °C at 760 mmHg
Molecular Formula C23H20N4O2 Melting Point N/A
MSDS N/A Flash Point 382.4±32.9 °C

 Use of Bisindolylmaleimide III


Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide III selectively interacts with either PKCα or ribosomal S6 protein kinase 1 after activation of these kinases[1].

 Names

Name Bisindolylmaleimide III
Synonym More Synonyms

 Bisindolylmaleimide III Biological Activity

Description Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide III selectively interacts with either PKCα or ribosomal S6 protein kinase 1 after activation of these kinases[1].
Related Catalog
Target

PKCα

References

[1]. Brehmer D, et, al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500.  

[2]. Saito Y, et, al. Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells. Mol Cell Endocrinol. 1999 Jun 25;152(1-2):65-72.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 708.7±60.0 °C at 760 mmHg
Molecular Formula C23H20N4O2
Molecular Weight 384.43
Flash Point 382.4±32.9 °C
Exact Mass 384.158630
PSA 92.91000
LogP 3.15
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.739

 Synonyms

1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
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