Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK

• 常用名: Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK
• 英文名: Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK
• CAS号: 1381885-28-4
• 分子量: 1666.158
• 密度: 1.2±0.1 g/cm3
• 沸点: 1659.8±65.0 °C at 760 mmHg
• 分子式: C₈₄H₁₄₀N₁₄O₁₈S
• 熔点: N/A
• 闪点: 957.6±34.3 °C

Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK用途

Z-VRPR-FMK是一种不可逆的MALT1蛋白抑制剂。Z-VRPR-FMK通过抑制MALT1诱导的NF-κB活化和MMP表达,抑制弥漫性大B细胞淋巴瘤的生长和侵袭[1]。

Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK名称

• 英文名: S-[2,3-Bis(palmitoyloxy)propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine

Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK生物活性

• 描述: Z-VRPR-FMK是一种不可逆的MALT1蛋白抑制剂。Z-VRPR-FMK通过抑制MALT1诱导的NF-κB活化和MMP表达,抑制弥漫性大B细胞淋巴瘤的生长和侵袭[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> NF-κB信号通路 >> MALT1
• 体外研究: Z-VRPR-FMK(50μM,24小时)可以有效降低 HBL-1型细胞核 c-REL公司水平,抑制了 核因子-κB的信号传导[2]。 Z-VRPR-FMK(50μM,48小时)对 ABC-DLBCL基因细胞系 HBL-1、TMD8、OCI-Ly3和 OCI-第10列具有一定的抑制增殖作用[2]。
• 参考文献:

  [1]. Jianglong Feng, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955.

  [2]. Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24.

Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 1659.8±65.0 °C at 760 mmHg
• 分子式: C₈₄H₁₄₀N₁₄O₁₈S
• 分子量: 1666.158
• 闪点: 957.6±34.3 °C
• 精确质量: 1665.019043
• LogP: 15.83
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.553

Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK靶点实验

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实验名称：Inhibition of MALT1 (unknown origin) expressed in PMA/IO-stimulated human Raji Glosen... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4341486

实验名称：Antiproliferative activity against human OCI-LY3 cells assessed as growth inhibition ... 来源：ChEMBL 靶标：OCI-Ly3 External Id：CHEMBL4341485

实验名称：Antiproliferative activity against human OCI-LY1 cells up to 20 uM 来源：ChEMBL 靶标：OCI-Ly1 External Id：CHEMBL4341533

实验名称：Inhibition of recombinant LZ-fused MALT1 (340 to 789 residues) (unknown origin) using... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4341484

实验名称：Inhibition of MALT1 in human OCI-LY3 cells assessed as reduction in Relb cleavage at ... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4341482

实验名称：Inhibition of recombinant human cathepsin B expressed in Escherichia coli BL21 (DE3) ... 来源：ChEMBL 靶标：Cathepsin B External Id：CHEMBL4359272

实验名称：Inhibition of full length wild type human N-terminal GST-tagged MALT1 catalytic domai... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4359271

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Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK英文别名

• S-[2,3-Bis(palmitoyloxy)propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine