IHVR-11029

• 常用名: IHVR-11029
• 英文名: IHVR-11029
• CAS号: 1383152-30-4
• 分子量: 375.41
• 密度: 1.3±0.1 g/cm3
• 沸点: 546.7±50.0 °C at 760 mmHg
• 分子式: C₁₈H₂₇F₂NO₅
• 熔点: N/A
• 闪点: 284.4±30.1 °C

IHVR-11029用途

IHVR-11029是ERα-葡萄糖苷酶的小分子抑制剂,EC50为0.09μM[1]。

IHVR-11029名称

• 英文名: (2R,3R,4R,5S)-1-[6-(2,5-Difluorophenoxy)hexyl]-2-(hydroxymethyl)-3,4,5-piperidinetriol

IHVR-11029生物活性

• 描述: IHVR-11029是ERα-葡萄糖苷酶的小分子抑制剂,EC50为0.09μM[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> 葡萄糖激酶
  研究领域 >> 炎症/免疫
• 靶点实验:

  EC50: 0.09 μM (ER α-glucosidases)[1].

• 体外研究: IHVR-11029对BVDV、TARV和DENV的EC50值分别为1.3μM、3.3μM和0.75μM。
• 参考文献:

  [1]. Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res. 2013 Jun;98(3):432-40.

IHVR-11029物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 546.7±50.0 °C at 760 mmHg
• 分子式: C₁₈H₂₇F₂NO₅
• 分子量: 375.41
• 闪点: 284.4±30.1 °C
• 精确质量: 375.185730
• LogP: 2.54
• InChIKey: XGCVJVFPIXDHPA-CYGHRXIMSA-N
• SMILES: OCC1C(O)C(O)C(O)CN1CCCCCCOc1cc(F)ccc1F
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.551
• 储存条件: 2-8°C，密封，干燥

IHVR-11029靶点实验

查看更多实验

实验名称：Antiviral activity against 0.01 MOI DENV-2 NGC infected in BHK cells assessed as redu... 来源：ChEMBL 靶标：dengue virus type 2 External Id：CHEMBL2167912

实验名称：Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV NADL infected in MDB... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167913

实验名称：Selectivity index, ratio of CC50 for BHK cells to EC50 for DENV-2 NGC infected in BHK... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167910

实验名称：Cytotoxicity against BHK cells assessed as cell viability by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167911

实验名称：Inhibition of human CYP3A4 using testosterone as substrate at 10 uM 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL2167916

实验名称：Inhibition of human CYP2D6 at 10 uM 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL2167917

实验名称：Cytotoxicity against MDBK cells assessed as cell viability by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167914

实验名称：Antiviral activity against 1 MOI BVDV NADL infected in MDBK cells assessed as reducti... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2167915

实验名称：Antiviral activity against 0.01 MOI DENV infected in human Huh7.5 cells assessed as r... 来源：ChEMBL 靶标：Dengue virus External Id：CHEMBL2167904

实验名称：Metabolic stability in mouse liver microsomes at 60 mins 来源：ChEMBL 靶标：Liver External Id：CHEMBL2167905

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IHVR-11029英文别名

• (2R,3R,4R,5S)-1-[6-(2,5-Difluorophenoxy)hexyl]-2-(hydroxymethyl)-3,4,5-piperidinetriol