MIRK-IN-1

• 常用名: MIRK-IN-1
• 英文名: TC-S 7004
• CAS号: 1386979-55-0
• 分子量: 498.318
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₁₇Cl₂N₅O₄
• 熔点: N/A
• 闪点: N/A

MIRK-IN-1用途

Mirk-IN-1(Dyrk1B/A-IN-1)是Dyrk1B和Dyrk1A高效选择性抑制剂，IC50值分别为68和22nM。

MIRK-IN-1名称

• 中文名: MIRK-IN-1
• 英文名: Mirk-IN-1

MIRK-IN-1生物活性

• 描述: Mirk-IN-1(Dyrk1B/A-IN-1)是Dyrk1B和Dyrk1A高效选择性抑制剂,IC50值分别为68和22nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> DYRK
  研究领域 >> 癌症
• 参考文献:

  [1]. Ewton DZ, et al. Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol Cancer Ther. 2011 Nov;10(11):2104-14.

  [2]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.

MIRK-IN-1物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₃H₁₇Cl₂N₅O₄
• 分子量: 498.318
• 精确质量: 497.065765
• LogP: 4.21
• InChIKey: CQKBSRPVZZLCJE-UHFFFAOYSA-N
• SMILES: COc1ncc2cc(C(=O)Nc3cc(C(=O)NCc4cccc(Cl)c4)ccc3Cl)c(=O)[nH]c2n1
• 折射率: 1.678
• 储存条件: 2-8℃

MIRK-IN-1靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Thermal Shift Assay. Domain start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4650107

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Thermal Shift Assay. Domain: start/stop: M26-R383 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL5066250

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Thermal Shift Assay. Domain: start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL5062534

实验名称：Incucyte cell viability with HEK293T 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL5058565

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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MIRK-IN-1英文别名

• N-{2-Chloro-5-[(3-chlorobenzyl)carbamoyl]phenyl}-2-methoxy-7-oxo-1,7-dihydropyrido[2,3-d]pyrimidine-6-carboxamide