Verdinexor

• 常用名: Verdinexor
• 英文名: Verdinexor
• CAS号: 1392136-43-4
• 分子量: 442.318
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₁₂F₆N₆O
• 熔点: N/A
• 闪点: N/A

Verdinexor用途

Verdinexor(KPT-335)是新型口服活性出核抑制剂(SINE),能有效抑制犬肿瘤细胞系出核蛋白Exportin 1(XPO1/CRM1),也能降低流感病毒的复制水平。

Verdinexor名称

• 中文名: Verdinexor
• 英文名: (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide

Verdinexor生物活性

• 描述: Verdinexor(KPT-335)是新型口服活性出核抑制剂(SINE),能有效抑制犬肿瘤细胞系出核蛋白Exportin 1(XPO1/CRM1),也能降低流感病毒的复制水平。
• 相关类别:
  信号通路 >> 跨膜转运 >> CRM1
  研究领域 >> 癌症
• 参考文献:

  [1]. Munuce MJ, et al. Effects of ulipristal acetate on sperm DNA fragmentation during in vitro incubation. Eur J Contracept Reprod Health Care. 2013 Oct;18(5):355-63.

  [2]. Pohl O, et al. Carcinogenicity and chronic rodent toxicity of the selective progesterone receptor modulator ulipristal acetate. Curr Drug Saf. 2013 Apr;8(2):77-97.

  [3]. Pohl O, et al. A 39-week oral toxicity study of ulipristal acetate in cynomolgus monkeys. Regul Toxicol Pharmacol. 2013 Jun;66(1):6-12.

  [4]. Attardi BJ, et al. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88.

  [5]. Ciarmela P, et al. Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. Reprod Sci. 2014 Sep;21(9):1120-5.

Verdinexor物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₈H₁₂F₆N₆O
• 分子量: 442.318
• 精确质量: 442.097687
• PSA: 88.22000
• LogP: 4.10
• InChIKey: OPAKEJZFFCECPN-XQRVVYSFSA-N
• SMILES: O=C(C=Cn1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1ccccn1
• 外观性状: 粉末
• 折射率: 1.577
• 储存条件: -20℃

Verdinexor靶点实验

查看更多实验

实验名称：Induction of XPO1 degradation in human Jurkat cells measured after 24 hrs by Western ... 来源：ChEMBL 靶标：Exportin-1 External Id：CHEMBL5526711

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Selectivity ratio of EC50 for cytotoxicity against human Jurkat cells to EC50 for inh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5526699

实验名称：Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5526698

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

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Verdinexor英文别名

• Verdinexor [INN]
• verdinexor
• (2Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)prop-2-enehydrazide
• KPT-335
• (2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyridinyl)acrylohydrazide
• 2-Propenoic acid,3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-,2-(2-pyridinyl)hydrazide,(2Z)