Selinexor

• 常用名: Selinexor
• 英文名: KPT 330
• CAS号: 1393477-72-9
• 分子量: 443.306
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₇H₁₁F₆N₇O
• 熔点: N/A
• 闪点: N/A

Selinexor名称

• 中文名: Selinexor
• 英文名: (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide

Selinexor生物活性

• 相关类别:
  信号通路 >> 跨膜转运 >> CRM1
  研究领域 >> 癌症
• 参考文献:

  [1]. Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013 Apr;161(1):117-27.

  [2]. Tai YT, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014 Jan;28(1):155-65.

Selinexor物理化学性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₁₇H₁₁F₆N₇O
• 分子量: 443.306
• 精确质量: 443.092926
• PSA: 97.62000
• LogP: 3.62
• InChIKey: DEVSOMFAQLZNKR-RJRFIUFISA-N
• SMILES: O=C(C=Cn1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1
• 折射率: 1.594
• 储存条件: -20℃

Selinexor英文别名

• UNII-31TZ62FO8F
• 2-Propenoic acid,3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-,2-(2-pyrazinyl)hydrazide,(2Z)
• (2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide
• selinexor
• (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide
• KPT-330
• Selinexor (KPT-330)