3-CPMT

• 常用名: 3-CPMT
• 英文名: 3-CPMT
• CAS号: 14008-79-8
• 分子量: 378.34
• 密度: N/A
• 沸点: 437.2ºC at 760mmHg
• 分子式: C₂₁H₂₅Cl₂NO
• 熔点: N/A
• 闪点: 218.2ºC

3-CPMT用途

3-CPMT(托品-4-氯苯甲醚盐酸盐)是一种强效的多巴胺摄取抑制剂[1]。3-CPMT(盐酸托品-4-氯苯甲醚)是一种有效的长效抗组胺剂[2]。

3-CPMT名称

• 英文名: 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane,hydrochloride

3-CPMT生物活性

• 描述: 3-CPMT(托品-4-氯苯甲醚盐酸盐)是一种强效的多巴胺摄取抑制剂[1]。3-CPMT(盐酸托品-4-氯苯甲醚)是一种有效的长效抗组胺剂[2]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 多巴胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. A H Newman, et al. Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles. J Med Chem. 1994 Jul 22;37(15):2258-61

  [2]. A H Newman, et al. Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles. J Med Chem. 1994 Jul 22;37(15):2258-61

3-CPMT物理化学性质

• 沸点: 437.2ºC at 760mmHg
• 分子式: C₂₁H₂₅Cl₂NO
• 分子量: 378.34
• 闪点: 218.2ºC
• 精确质量: 377.13100
• PSA: 12.47000
• LogP: 5.81110
• InChIKey: FXKCQWIUITUJFU-UHFFFAOYSA-N
• SMILES: CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2.Cl
• 蒸汽压: 7.62E-08mmHg at 25°C

3-CPMT毒性和生态

3-CPMT安全信息

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S26
• WGK德国: 3

3-CPMT靶点实验

查看更多实验

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：ULK1_INH_LUMI_1536_1X%INH PRUN

实验名称：qHTS for Inhibitors of Polymerase Iota 来源：NCGC 靶标：DNA polymerase iota [Homo sapiens] External Id：PolI100

实验名称：qHTS for Inhibitors of Polymerase Eta 来源：NCGC 靶标：DNA polymerase eta [Homo sapiens] External Id：PolE100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1):... 来源：NCGC 靶标：thioredoxin reductase [Rattus norvegicus] External Id：TRXR100

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

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3-CPMT英文别名

• Clobenztropin-hydrochlorid
• Chlortropbenzyl
• Desipramine hydrochloride
• WY 2149
• SL-6057
• FC-1
• 3-CPMT
• Tropine 4-chlorobenzhydryl ether hydrochloride