GB-88

• 常用名: GB-88
• 英文名: GB-88
• CAS号: 1416435-96-5
• 分子量: 546.70
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂H₄₂N₄O₄
• 熔点: N/A
• 闪点: N/A

GB-88用途

GB-88 是一种选择性的口服 PAR2 拮抗剂,抑制 PAR2 激活 Ca(2+) 释放的IC50 值为 2 µM。

GB-88名称

• 中文名: GB-88
• 英文名: GB-88

GB-88生物活性

• 描述: GB-88 是一种选择性的口服 PAR2 拮抗剂,抑制 PAR2 激活 Ca(2+) 释放的IC50 值为 2 µM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 蛋白酶激活受体(PAR)
  研究领域 >> 炎症/免疫
• 靶点实验:

  PAR2[1]

• 参考文献:

  [1]. Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23.

GB-88物理化学性质

• 分子式: C₃₂H₄₂N₄O₄
• 分子量: 546.70
• InChIKey: DCUDDCGUKZLQLN-MCOVPRHSSA-N
• SMILES: CCC(C)C(NC(=O)C(CC1CCCCC1)NC(=O)c1ccno1)C(=O)N1CCC2(C=Cc3ccccc32)CC1
• 储存条件: -20°C

GB-88靶点实验

查看更多实验

实验名称：Agonist activity at PAR2 in human HT-29 cells assessed as induction of ca2+ release a... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL3757292

实验名称：Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of trypsin-in... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL3757296

实验名称：Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL3757294

实验名称：Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL3757293

实验名称：Stability in Wistar rat plasma at 10 uM measured up to 3 hrs by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL3867389

实验名称：Antagonist activity at PAR1 in human PC3 cells assessed as inhibition of TFLLR-induce... 来源：ChEMBL 靶标：Proteinase-activated receptor 1 External Id：CHEMBL3757298

实验名称：Elimination half life in Wistar rat liver homogenate at 10 uM by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL3867390

实验名称：Antagonist activity at PAR1 in human PC3 cells assessed as inhibition of alpha-thromb... 来源：ChEMBL 靶标：Proteinase-activated receptor 1 External Id：CHEMBL3757297

实验名称：Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-... 来源：ChEMBL 靶标：Proteinase-activated receptor 2 External Id：CHEMBL3867391

实验名称：AUC (0 to 6 hrs) in Wistar rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3757304

共15条，当前第1页，共2页

1

2