突变体IDH1-IN-2

• 常用名: 突变体IDH1-IN-2
• 英文名: Mutant IDH1-IN-2
• CAS号: 1429176-69-1
• 分子量: 459.532
• 密度: 1.3±0.1 g/cm3
• 沸点: 578.1±60.0 °C at 760 mmHg
• 分子式: C₂₄H₃₁F₂N₅O₂
• 熔点: N/A
• 闪点: 303.4±32.9 °C

突变体IDH1-IN-2用途

Mutant IDH1-IN-2是一种突变型异柠檬酸脱氢酶 (IDH) 蛋白抑制剂, 在LS-MS生物化学检测中IC50值为＜22 nM, 荧光生物化学检测中IC50值为16.6 nM。

突变体IDH1-IN-2名称

• 中文名: 突变体IDH1-IN-2
• 英文名: Mutant IDH1-IN-2

突变体IDH1-IN-2生物活性

• 描述: Mutant IDH1-IN-2是一种突变型异柠檬酸脱氢酶 (IDH) 蛋白抑制剂, 在LS-MS生物化学检测中IC50值为＜22 nM, 荧光生物化学检测中IC50值为16.6 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 异柠檬酸脱氢酶(IDH)
  研究领域 >> 癌症
• 参考文献:

  [1]. Huangshu, et al. 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation

突变体IDH1-IN-2物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 578.1±60.0 °C at 760 mmHg
• 分子式: C₂₄H₃₁F₂N₅O₂
• 分子量: 459.532
• 闪点: 303.4±32.9 °C
• 精确质量: 459.244568
• LogP: 2.72
• InChIKey: OCZCXJFDMAWAIM-FXAWDEMLSA-N
• SMILES: CC(Nc1nccc(N2C(=O)OCC2C(C)C)n1)c1ccc(CN2CCC(F)(F)CC2)cc1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.587
• 储存条件: 2-8℃

突变体IDH1-IN-2靶点实验

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实验名称：Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL5356485

实验名称：Selectivity index, ratio of IC50 for recombinant wildtype IDH1 expressed in Escherich... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5356486

实验名称：Fluorescence Biochemical Assay from US Patent US8957068: "3-pyrimidin-4-yl-oxazolidin... 来源：BindingDB 靶标：N/A External Id：BindingDB_6684_2

实验名称：Inhibition of recombinant wildtype IDH1 (unknown origin) expressed in Escherichia col... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL5356484

实验名称：LC-MS Biochemical Assay from US Patent US8957068: "3-pyrimidin-4-yl-oxazolidin-2-ones... 来源：BindingDB 靶标：N/A External Id：BindingDB_6684_1

实验名称：Inhibition of recombinant wildtype IDH1 (unknown origin) expressed in Escherichia col... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL5356497

实验名称：Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL5356498

实验名称：Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL5356507

实验名称：Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL5356488

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突变体IDH1-IN-2英文别名

• (4S)-3-(2-{[(1S)-1-{4-[(4,4-Difluoro-1-piperidinyl)methyl]phenyl}ethyl]amino}-4-pyrimidinyl)-4-isopropyl-1,3-oxazolidin-2-one