依克立达盐酸盐

• 常用名: 依克立达盐酸盐
• 英文名: Elacridar hydrochloride
• CAS号: 143851-98-3
• 分子量: 600.10400
• 密度: N/A
• 沸点: 701.6ºC at 760 mmHg
• 分子式: C₃₄H₃₄ClN₃O₅
• 熔点: N/A
• 闪点: 378.1ºC

依克立达盐酸盐用途

Elacridar(GF120918; GW0918)盐酸盐是P-糖蛋白抑制剂,在体内外实验中常作为工具化合物。

依克立达盐酸盐名称

• 中文名: 依克立达盐酸盐
• 英文名: N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide,hydrochloride

依克立达盐酸盐生物活性

• 描述: Elacridar(GF120918; GW0918)盐酸盐是P-糖蛋白抑制剂,在体内外实验中常作为工具化合物。
• 相关类别:
  信号通路 >> 跨膜转运 >> P-糖蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Sane R, Mittapalli RK, Elmquist WF. Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability. J Pharm Sci. 2013 Jan 18.

  [2]. Bankstahl JP, Bankstahl M, Romermann K, et al. Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal PET and In-Vitro Study. Drug Metab Dispos. 2013 Jan 10.

  [3]. Sane R, Agarwal S, Elmquist WF. Brain distribution and bioavailability of elacridar after different routes of administration in the mouse. Drug Metab Dispos. 2012 Aug;40(8):1612-9.

  [4]. Tang SC, Lagas JS, Lankheet NA, et al. Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int J Cancer. 2012 Jan 1;130(1):223-33. doi: 10.1002/ijc.26000.

  [5]. Kuppens IE, Witteveen EO, Jewell RC, et al. A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients. Clin Cancer Res. 2007 Jun 1;13(11):3276-85.

  [6]. Hong Xiao, et al. Polymeric nanovesicle as simultaneous delivery platform with Doxorubicin conjugation and Elacridar encapsulation for enhanced treatment of multidrug-resistant breast cancer. J. Mater. Chem. B. 2018 Oct.

依克立达盐酸盐物理化学性质

• 沸点: 701.6ºC at 760 mmHg
• 分子式: C₃₄H₃₄ClN₃O₅
• 分子量: 600.10400
• 闪点: 378.1ºC
• 精确质量: 599.21900
• PSA: 92.89000
• LogP: 6.37310
• 蒸汽压: 1.57E-19mmHg at 25°C
• 储存条件: 2-8℃

依克立达盐酸盐安全信息

• 海关编码: 2934999090

依克立达盐酸盐海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

依克立达盐酸盐英文别名

• UNII-NX2BHH1A5B
• Elacridar HCl
• Elacridar hydrochloride
• Elacridar hydrochloride (USAN)
• Elacridar (hydrochloride)