甘草查尔酮D

• 常用名: 甘草查尔酮D
• 英文名: Licochalcone D
• CAS号: 144506-15-0
• 分子量: 354.39600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₂O₅
• 熔点: N/A
• 闪点: N/A

甘草查尔酮D用途

Licochalcone D 是存在于Glycyrrhiza inflate 中的黄酮类化合物,是NF-κB p65 的有效抑制剂。Licochalcone D 具有抗氧化、抗炎、抗癌等作用。

甘草查尔酮D名称

• 中文名: 甘草查尔酮 D
• 英文名: (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
• 中文别名: 甘草查尔酮D

甘草查尔酮D生物活性

• 描述: Licochalcone D 是存在于Glycyrrhiza inflate 中的黄酮类化合物,是NF-κB p65 的有效抑制剂。Licochalcone D 具有抗氧化、抗炎、抗癌等作用。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 靶点实验:

  p65

• 参考文献:

  [1]. Furusawa J, et al. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. 2009 Apr;9(4):499-507.

  [2]. Si L, et al. Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells. Oncol Rep. 2018 May;39(5):2160-2170.

甘草查尔酮D物理化学性质

• 分子式: C₂₁H₂₂O₅
• 分子量: 354.39600
• 精确质量: 354.14700
• PSA: 86.99000
• LogP: 4.21680
• InChIKey: RETRVWFVEFCGOK-RMKNXTFCSA-N
• SMILES: COc1c(C=CC(=O)c2ccc(O)c(CC=C(C)C)c2)ccc(O)c1O
• 储存条件: 2-8℃

甘草查尔酮D靶点实验

查看更多实验

实验名称：Inhibition of Influenza A H1N1 virus neuraminidase activity after 2 hrs by spectroflu... 来源：ChEMBL 靶标：Neuraminidase External Id：CHEMBL1645794

实验名称：Cytotoxicity in human HepG2 cells expressing Nrf2/ARE-driven luciferase at 20 to 40 u... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4046720

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046717

实验名称：Inhibition of Influenza A H9N2 virus neuraminidase activity after 2 hrs by spectroflu... 来源：ChEMBL 靶标：Neuraminidase External Id：CHEMBL1645797

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 2.5 to 20 uM in... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046718

实验名称：Noncompetitive inhibition of Influenza A H1N1 virus neuraminidase activity by Linewea... 来源：ChEMBL 靶标：Neuraminidase External Id：CHEMBL1645798

实验名称：Antibacterial activity against Bacillus subtilis IFO 3060 assessed bacterial growth i... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL5367159

实验名称：Antibacterial activity against Micrococcus luteus IFO 3333 assessed bacterial growth ... 来源：ChEMBL 靶标：Micrococcus luteus External Id：CHEMBL5367160

实验名称：Antibacterial activity against Staphylococcus aureus IFO 3007 assessed bacterial grow... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5367158

实验名称：Inhibition of Clostridium perfringens neuraminidase 来源：ChEMBL 靶标：Sialidase External Id：CHEMBL1645800

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甘草查尔酮D英文别名

• UNII-3P0SH94V09
• Licochalcone D