Chlojaponilactone B

• 常用名: Chlojaponilactone B
• 英文名: Chlojaponilactone B
• CAS号: 1449382-91-5
• 分子量: 286.322
• 密度: 1.3±0.1 g/cm3
• 沸点: 458.9±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈O₄
• 熔点: N/A
• 闪点: 236.2±27.1 °C

Chlojaponilactone B用途

Chlojaponilactone B 是一种具有抗炎特性的茚烷型倍半萜类化合物。Chlojaponilactone B 通过抑制 TLR4 并随后减少活性氧 (ROS) 的产生、下调 NF-κB 来抑制炎症反应,从而减少促炎细胞因子 iNOS、NO、COX-2、IL-6 和 TNF-α 的表达。

Chlojaponilactone B名称

• 英文名: (4R,4aS,5aS,6aR,6bS)-3,6b-Dimethyl-5-methylene-2-oxo-2,4,4a,5,5a,6,6a,6b-octahydrocyclopropa[2,3]indeno[5,6-b]furan-4-yl acetate

Chlojaponilactone B生物活性

• 描述: Chlojaponilactone B 是一种具有抗炎特性的茚烷型倍半萜类化合物。Chlojaponilactone B 通过抑制 TLR4 并随后减少活性氧 (ROS) 的产生、下调 NF-κB 来抑制炎症反应,从而减少促炎细胞因子 iNOS、NO、COX-2、IL-6 和 TNF-α 的表达。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Shaoxia Ye, et al. Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway. Molecules. 2019 Oct 16;24(20):3731.

Chlojaponilactone B物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 458.9±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈O₄
• 分子量: 286.322
• 闪点: 236.2±27.1 °C
• 精确质量: 286.120514
• LogP: 2.76
• InChIKey: DJENQWQXZQCLHL-PVBKFEAWSA-N
• SMILES: C=C1C2CC2C2(C)C=C3OC(=O)C(C)=C3C(OC(C)=O)C12
• 外观性状: 粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.583
• 储存条件: 2-8℃

Chlojaponilactone B靶点实验

查看更多实验

实验名称：Inhibition of NF-kappaB in mouse RAW264.7 cells assessed as reduction in LPS-induced ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3869121

实验名称：Inhibition of NF-kappaB in mouse RAW264.7 cells assessed as reduction in LPS-induced ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3869122

实验名称：Inhibition of NF-kappaB in mouse RAW264.7 cells assessed as reduction in LPS-induced ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3869123

实验名称：Antiinflammatory activity in BALB/c mouse assessed as inhibition of TPA-induced ear e... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3869124

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3869120

实验名称：Inhibition of LPS-induced JNK phosphorylation in mouse RAW264.7 cells at 2.5 to 10 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3869129

实验名称：Inhibition of LPS-induced MAPK p38 phosphorylation in mouse RAW264.7 cells at 2.5 to ... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 11 External Id：CHEMBL3869130

实验名称：Inhibition of LPS-induced ERK1/2 phosphorylation in mouse RAW264.7 cells at 2.5 to 10... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 3 External Id：CHEMBL3869131

实验名称：Inhibition of NF-kappaB in mouse RAW264.7 cells assessed as reduction in LPS-induced ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3869132

实验名称：Antiinflammatory activity in BALB/c mouse assessed as inhibition of TPA-induced ear e... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3869125

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Chlojaponilactone B英文别名

• (4R,4aS,5aS,6aR,6bS)-3,6b-Dimethyl-5-methylene-2-oxo-2,4,4a,5,5a,6,6a,6b-octahydrocyclopropa[2,3]indeno[5,6-b]furan-4-yl acetate