TIPP

• 常用名: TIPP
• 英文名: TIPP
• CAS号: 146369-65-5
• 分子量: 634.72
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₇H₃₈N₄O₆
• 熔点: N/A
• 闪点: N/A

TIPP用途

TIPP是一种强效和选择性的δ-阿片类拮抗剂,Ki值为1.22nM[1]。

TIPP名称

• 中文名: TIPP
• 英文名: (2S)-2-[[(2S)-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid

TIPP生物活性

• 描述: TIPP是一种强效和选择性的δ-阿片类拮抗剂,Ki值为1.22nM[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Schiller PW, et al. The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers. 1999;51(6):411-25.

TIPP物理化学性质

• 分子式: C₃₇H₃₈N₄O₆
• 分子量: 634.72
• 精确质量: 634.27900
• PSA: 162.06000
• LogP: 4.17510
• InChIKey: JYOUATXRHWNDDW-YRCZKMHPSA-N
• SMILES: NC(Cc1ccc(O)cc1)C(=O)N1Cc2ccccc2CC1C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)O

TIPP靶点实验

查看更多实验

实验名称：Antagonist activity at human delta opioid receptor expressed in HEK293 cells by [35S]... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL2215462

实验名称：Tested for antagonistic activity against delta opioid receptor from mouse vas deferen... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL751661

实验名称：Relative potency to that of [Leu5]- enkephalin 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL843456

实验名称：Agonist activity at human delta opioid receptor expressed in HEK293 cells by [35S]GTP... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL2215461

实验名称：Displacement of [3H]DSLET from delta opioid receptor in rat brain membrane after 2 hr... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL2215009

实验名称：Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membrane a... 来源：ChEMBL 靶标：Kappa-type opioid receptor External Id：CHEMBL2215451

实验名称：Tested for antagonistic activity against delta opioid receptor from mouse vas deferen... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL751662

实验名称：Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane after 2 hrs 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL2215008

实验名称：Tested for binding affinity against mu opioid receptor fby displacing [3H]- DAMGO rad... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL844218

实验名称：Binding affinity towards Opioid receptor kappa 1 on guinea pig cerebellum membranes b... 来源：ChEMBL 靶标：Kappa-type opioid receptor External Id：CHEMBL754736

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TIPP英文别名

• Tyr-tic-phe-phe-OH
• H-Tyr-Tic-Phe-Phe-OH
• L-Phenylalanine,L-tyrosyl-L-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-phenylalanyl
• TIPP