K-Ras(G12C) inhibitor 9

• 常用名: K-Ras(G12C) inhibitor 9
• 英文名: K-Ras(G12C) inhibitor 9
• CAS号: 1469337-91-4
• 分子量: 513.77800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₂₁ClIN₃O₄S
• 熔点: N/A
• 闪点: N/A

K-Ras(G12C) inhibitor 9用途

K-Ras(G12C)抑制剂9是K-Ras(G12C)的变构抑制剂[1]。

K-Ras(G12C) inhibitor 9名称

• 英文名: Ethenesulfonamide, N-​[1-​[2-​[(4-​chloro-​5-​iodo-​2-​methoxyphenyl)​amino]​acetyl]​-​4-​piperidinyl]​

K-Ras(G12C) inhibitor 9生物活性

• 描述: K-Ras(G12C)抑制剂9是K-Ras(G12C)的变构抑制剂[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
• 参考文献:

  [1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

K-Ras(G12C) inhibitor 9物理化学性质

• 分子式: C₁₆H₂₁ClIN₃O₄S
• 分子量: 513.77800
• 精确质量: 512.99900
• PSA: 96.12000
• LogP: 3.90160
• InChIKey: ZGUSBCDCZNBNQT-UHFFFAOYSA-N
• SMILES: C=CS(=O)(=O)NC1CCN(C(=O)CNc2cc(I)c(Cl)cc2OC)CC1
• 储存条件: 2~8°C

K-Ras(G12C) inhibitor 9安全信息

• 危害码 (欧洲): Xi

K-Ras(G12C) inhibitor 9靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Binding affinity to hexa-histidine-tagged recombinant human K-Ras isoform 2 G12C muta... 来源：ChEMBL 靶标：GTPase KRas External Id：CHEMBL4271416

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Inhibition of N-terminal GST-tagged recombinant human MKK3 S198E/T193E mutant express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5550262

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant ass... 来源：ChEMBL 靶标：NCI-H23 External Id：CHEMBL5248836

实验名称：Rucaparib conditional oncology-focused drug screen on ovarian cancer cells. 来源：24139 靶标：N/A External Id：Rucaparib conditional drug screen of ovarian cancer cells

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K-Ras(G12C) inhibitor 9英文别名

• K-Ras(G12C) inhibitor 9