K-Ras(G12C) inhibitor 12

• 常用名: K-Ras(G12C) inhibitor 12
• 英文名: K-Ras(G12C) inhibitor 12
• CAS号: 1469337-95-8
• 分子量: 449.671
• 密度: 1.736±0.06 g/cm3
• 沸点: 680.2±55.0 °C at 760 mmHg
• 分子式: C₁₅H₁₇ClIN₃O₃
• 熔点: N/A
• 闪点: 365.2±31.5 °C

K-Ras(G12C) inhibitor 12用途

K-Ras(G12C) inhibitor 12是K-Ras(G12C)抑制剂, K-Ras(G12C) inhibitor 12作用于H1792细胞, EC50为0.32 μM。

K-Ras(G12C) inhibitor 12作用

体外活性：K-Ras(G12C) inhibitor 12属于一系列小分子，其不可逆结合于共同的致瘤性突变体K-Ras(G12C)，并阻断K-Ras(G12C)相互作用。他们中的一些降低活性，并增加含G12C的癌细胞系凋亡。

K-Ras(G12C) inhibitor 12名称

• 中文名: 1-[4-[2-[(4-氯-2-羟基-5-碘苯基)氨基]乙酰基]-1-哌嗪基]-2-丙烯-1-酮
• 英文名: 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one

K-Ras(G12C) inhibitor 12生物活性

• 描述: K-Ras(G12C) inhibitor 12是K-Ras(G12C)抑制剂, K-Ras(G12C) inhibitor 12作用于H1792细胞, EC50为0.32 μM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
  研究领域 >> 癌症
• 参考文献:

  [1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-551.

K-Ras(G12C) inhibitor 12物理化学性质

• 密度: 1.736±0.06 g/cm3
• 沸点: 680.2±55.0 °C at 760 mmHg
• 分子式: C₁₅H₁₇ClIN₃O₃
• 分子量: 449.671
• 闪点: 365.2±31.5 °C
• 精确质量: 449.000305
• PSA: 72.88000
• LogP: 2.84
• InChIKey: JFIFBWVNHLXJFY-UHFFFAOYSA-N
• SMILES: C=CC(=O)N1CCN(C(=O)CNc2cc(I)c(Cl)cc2O)CC1
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.674
• 水溶解性: Practically insoluble (0.01 g/L) (25 ºC)

K-Ras(G12C) inhibitor 12安全信息

• 海关编码: 2933599090

K-Ras(G12C) inhibitor 12海关

• 海关编码: 2933599090
• 中文概述: 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

K-Ras(G12C) inhibitor 12靶点实验

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实验名称：Binding affinity to hexa-histidine-tagged recombinant human K-Ras isoform 2 G12C muta... 来源：ChEMBL 靶标：GTPase KRas External Id：CHEMBL4271416

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K-Ras(G12C) inhibitor 12英文别名

• 1-(4-(2-((4-Chloro-2-hydroxy-5-iodophenyl)amino)acetyl)piperazin-1-yl)prop-2-en-1-one
• 1-(4-{[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl}-1-piperazinyl)-2-propen-1-one
• K-Ras(G12C) inhibitor 12
• 1-[4-[2-[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-2-propen-1-one