K-Ras(G12C) inhibitor 12

Modify Date: 2024-01-02 16:52:41

K-Ras(G12C) inhibitor 12 structure	Common Name	K-Ras(G12C) inhibitor 12
	CAS Number	1469337-95-8	Molecular Weight	449.671
	Density	1.736±0.06 g/cm3	Boiling Point	680.2±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₇ClIN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	365.2±31.5 °C

Use of K-Ras(G12C) inhibitor 12

K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.IC50 value: 0.32 μM (EC50)Target: K-RasBinding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K-Ras(G12C) inhibitor 12, K-Ras(G12C) shows a slight preference for GTP (relative affinity 0.6).

Name	1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one
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Description	K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.IC50 value: 0.32 μM (EC50)Target: K-RasBinding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K-Ras(G12C) inhibitor 12, K-Ras(G12C) shows a slight preference for GTP (relative affinity 0.6).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Ras Research Areas >> Cancer
References	[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-551.

Density	1.736±0.06 g/cm3
Boiling Point	680.2±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₇ClIN₃O₃
Molecular Weight	449.671
Flash Point	365.2±31.5 °C
Exact Mass	449.000305
PSA	72.88000
LogP	2.84
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.674
Water Solubility	Practically insoluble (0.01 g/L) (25 ºC)

HS Code	2933599090

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-(4-(2-((4-Chloro-2-hydroxy-5-iodophenyl)amino)acetyl)piperazin-1-yl)prop-2-en-1-one

2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-

1-(4-{[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl}-1-piperazinyl)-2-propen-1-one

K-Ras(G12C) inhibitor 12

1-[4-[2-[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-2-propen-1-one

DC Chemicals Limited
China
Product Name: K-Ras(G12C) inhibitor 12
Price: $650.0/100mg $1050.0/250mg $2100.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(4-(2-((4-chloro-2-hydroxy-5-iodophenyl)amino)acetyl)piperazin-1-yl)prop-2-en-1-one
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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K-Ras(G12C) inhibitor 12

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