萘夫西林

• 常用名: 萘夫西林
• 英文名: nafcillin
• CAS号: 147-52-4
• 分子量: 414.475
• 密度: 1.4±0.1 g/cm3
• 沸点: 714.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂N₂O₅S
• 熔点: N/A
• 闪点: 385.7±32.9 °C

萘夫西林用途

萘西林是一种抗生素,是β-内酰胺酶的可逆抑制剂。萘西林具有杀菌活性,可用于葡萄球菌感染的研究[1][2][3][4]。

萘夫西林名称

• 中文名: 萘夫西林
• 英文名: nafcillin

萘夫西林生物活性

• 描述: 萘西林是一种抗生素,是β-内酰胺酶的可逆抑制剂。萘西林具有杀菌活性,可用于葡萄球菌感染的研究[1][2][3][4]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体内研究: 萘西林(100 mg/kg；s.c.)对甲氧西林敏感的金黄色葡萄球菌(MSSA)和耐甲氧西林金黄色葡萄菌(MRSA)具有杀菌活性,对金黄色葡萄杆菌菌株Xen-29和Xen-1的MIC分别为0.5μg/mL和64.0μg/mL[3]。
• 参考文献:

  [1]. Tan, A.K., et al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J, 1992. 281 ( Pt 1): p. 191-6.

  [2]. Palmer, D.L., et al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg, 1995. 59(3): p. 626-31.

  [3]. Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51(5): 1787-1794.

  [4]. Sakoulas G, et al. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl). 2014 Feb;92(2):139-49.

萘夫西林物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 714.1±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₂N₂O₅S
• 分子量: 414.475
• 闪点: 385.7±32.9 °C
• 精确质量: 414.124939
• PSA: 121.24000
• LogP: 3.52
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.686

萘夫西林毒性和生态

萘夫西林英文别名

• Propizepina
• 6-(2-dimethylamino-propyl)-6,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one
• 6-(2-Ethoxy-naphth-1-yl-formamino)penicillansaeure
• nafcillinum [INN_la]
• (2S,5R,6R)-6-({[2-(ethyloxy)naphthalen-1-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• Propizepinum
• (2-ethoxy-naphthalen-1-yl)-penicillin
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• [2S-(2a,5a,6b)]-6-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
• Naftopen
• Nallpen
• Propizepinum [INN-Latin]
• 6-(2-Ethoxy-1-naphthamido)penicillin
• Propizepina [INN-Spanish]
• Vagran 50 Kapseln
• Propizepine
• (2S,5R,6R)-6-[(2-Ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid