雷尼司他

• 常用名: 雷尼司他
• 英文名: Ranirestat
• CAS号: 147254-64-6
• 分子量: 420.18900
• 密度: 1.83g/cm3
• 沸点: 702.7ºC at 760mmHg
• 分子式: C₁₇H₁₁BrFN₃O₄
• 熔点: N/A
• 闪点: 378.8ºC
• 符号: GHS07
• 信号词: Warning

雷尼司他用途

Ranirestat (AS-3201)是醛糖还原酶抑制剂,糖尿病性神经病变临床3期。

雷尼司他名称

• 中文名: 雷尼司他
• 英文名: (3R)-2'-[(4-bromo-2-fluorophenyl)methyl]spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5-tetrone

雷尼司他生物活性

• 描述: Ranirestat (AS-3201)是醛糖还原酶抑制剂,糖尿病性神经病变临床3期。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 醛糖还原酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Kurono M, et al. Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability. Biochem Pharmacol. 2006 Jan 12;7

  [2]. Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10.

  [3]. Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.

雷尼司他物理化学性质

• 密度: 1.83g/cm3
• 沸点: 702.7ºC at 760mmHg
• 分子式: C₁₇H₁₁BrFN₃O₄
• 分子量: 420.18900
• 闪点: 378.8ºC
• 精确质量: 418.99200
• PSA: 91.97000
• LogP: 1.52790
• InChIKey: QCVNMNYRNIMDKV-QGZVFWFLSA-N
• SMILES: O=C1CC2(C(=O)N1)C(=O)N(Cc1ccc(Br)cc1F)C(=O)c1cccn12
• 蒸汽压: 1.36E-19mmHg at 25°C
• 折射率: 1.749
• 储存条件: 2-8℃

雷尼司他安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
• 危险品运输编码: NONH for all modes of transport
• RTECS号: WH1441246

雷尼司他靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Inhibition of aldose reductase 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B1 External Id：CHEMBL924228

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：In vitro inhibitory activity against aldose reductase in porcine lens. 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B1 External Id：CHEMBL643203

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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雷尼司他英文别名

• (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidin-3,4'(1'H)-pyrrolo[1,2-a]pyrazin]-1',2,3',5(2'H)-tetraone
• Ranirestat
• Ranirestat (JAN/INN)
• (R)-2-(4-bromo-2-fluorobenzyl)spiro[1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4,3'-pyrrolidine]-1,2',3,5'-tetrone
• R-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro[1,2-a]pyrrolopyridine-4-spiro-3'-pyrrolidine-1,2',3'5'-tetraone
• SX-3202
• (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2H')-tetraone
• AS-3201
• SX 3030