1-[(2'-[(乙氧羰基)氧基]脒基)[1,1-联苯基]-4-基)甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸甲酯

• 常用名: 1-[(2'-[(乙氧羰基)氧基]脒基)[1,1-联苯基]-4-基)甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸甲酯
• 英文名: 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester
• CAS号: 147403-52-9
• 分子量: 470.477
• 密度: 1.4±0.1 g/cm3
• 沸点: 652.0±65.0 °C at 760 mmHg
• 分子式: C₂₆H₂₂N₄O₅
• 熔点: N/A
• 闪点: 348.1±34.3 °C

用途

Azilsartanmethylester 是 Azilsartan (HY-14914) 的衍生物,是一种血管紧张素 II 受体拮抗剂,在高血压中发挥重要作用。

名称

• 中文名: 1-[[2-(2,5-二氢-5-氧代-1,2,4-噁二唑-3-基)[1,1-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸甲酯
• 英文名: methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 中文别名: 1-[(2'-[(乙氧羰基)氧基]脒基)[1,1-联苯基]-4-基)甲基]-2-乙氧基-1H-苯并咪唑-7-甲酸甲酯 | 阿齐沙坦-a04 | 阿齐沙坦甲酯

生物活性

• 描述: Azilsartanmethylester 是 Azilsartan (HY-14914) 的衍生物,是一种血管紧张素 II 受体拮抗剂,在高血压中发挥重要作用。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
• 参考文献:

  [1]. Alison Handley, et al. Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study. Clin Exp Hypertens. 2016;38(2):180-8.

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 652.0±65.0 °C at 760 mmHg
• 分子式: C₂₆H₂₂N₄O₅
• 分子量: 470.477
• 闪点: 348.1±34.3 °C
• 精确质量: 470.159027
• PSA: 112.24000
• LogP: 4.51
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.665
• 储存条件: 室温，干燥

安全信息

• 危害码 (欧洲): Xi

靶点实验

查看更多实验

实验名称：Percent inhibition of angiotensin II (0.1 ug/kg iv) -induced pressor response 3h afte... 来源：ChEMBL 靶标：Type-2 angiotensin II receptor External Id：CHEMBL878959

实验名称：Percent inhibition of angiotensin II (0.1 ug/kg iv) -induced pressor response 7 hr af... 来源：ChEMBL 靶标：Type-2 angiotensin II receptor External Id：CHEMBL783565

实验名称：Inhibition of specific binding of [125I]angiotensin II (0.2 nM) to angiotensin II rec... 来源：ChEMBL 靶标：N/A External Id：CHEMBL646983

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英文别名

• methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
• Methyl 2-ethoxy-1-{[2'-(5-hydroxy-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
• 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, methyl ester
• Methyl 2-ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate
• methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
• methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
• methyl 1-[[2'-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate
• 1H-Benzimidazole-7-carboxylic acid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-,methyl ester
• BEN731
• 1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1h-benzimidazole-7-carboxylic acid methyl ester