1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester

Modify Date: 2025-08-24 18:16:23

1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester structure	Common Name	1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester
	CAS Number	147403-52-9	Molecular Weight	470.477
	Density	1.4±0.1 g/cm3	Boiling Point	652.0±65.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₂₂N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	348.1±34.3 °C

Use of 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester

Azilsartan methyl ester, a derivative of Azilsartan (HY-14914), is an angiotensin II receptor antagonist that plays an important role in hypertension[1].

Name	methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Synonym	More Synonyms

Description	Azilsartan methyl ester, a derivative of Azilsartan (HY-14914), is an angiotensin II receptor antagonist that plays an important role in hypertension[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
References	[1]. Alison Handley, et al. Safety and tolerability of azilsartan medoxomil in subjects with essential hypertension: a one-year, phase 3, open-label study. Clin Exp Hypertens. 2016;38(2):180-8.

Density	1.4±0.1 g/cm3
Boiling Point	652.0±65.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₂N₄O₅
Molecular Weight	470.477
Flash Point	348.1±34.3 °C
Exact Mass	470.159027
PSA	112.24000
LogP	4.51
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.665

Hazard Codes	Xi

Precursor 7
CAS#:102-09-0 Diphenyl carbonate CAS#:147403-65-4 2-Ethoxy-1-[[2'... CAS#:32315-10-9 Triphosgene CAS#:503-38-8 Diphosgene
CAS#:530-62-1 N,N-Carbonyldii... CAS#:105-58-8 Ethyl carbonate CAS#:616-38-6 Dimethyl Carbonate
DownStream 2
CAS#:863031-21-4 Azilsartan medoxomil CAS#:147403-03-0 Azilsartan

Name: Percent inhibition of angiotensin II (0.1 ug/kg iv) -induced pressor response 3h afte...
Source: ChEMBL
Target: Type-2 angiotensin II receptor
External Id: CHEMBL878959

Name: Percent inhibition of angiotensin II (0.1 ug/kg iv) -induced pressor response 7 hr af...
Source: ChEMBL
Target: Type-2 angiotensin II receptor
External Id: CHEMBL783565

Name: Inhibition of specific binding of [125I]angiotensin II (0.2 nM) to angiotensin II rec...
Source: ChEMBL
Target: N/A
External Id: CHEMBL646983

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methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Methyl 2-ethoxy-1-{[2'-(5-hydroxy-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, methyl ester

Methyl 2-ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylate

methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

methyl 1-[[2'-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate

1H-Benzimidazole-7-carboxylic acid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-,methyl ester

BEN731

1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1h-benzimidazole-7-carboxylic acid methyl ester

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester

Use of 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.