2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate结构式
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常用名 | 2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate | 英文名 | 2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate |
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| CAS号 | 148868-55-7 | 分子量 | 312.79200 | |
| 密度 | 1.223g/cm3 | 沸点 | 472.7ºC at 760 mmHg | |
| 分子式 | C15H21ClN2O3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 239.7ºC |
用途ML 10302是一种有效的激动剂5-HT4受体,Ki为1.07 nM。5-羟色胺(5-HT4)受体激动剂通过胆碱能途径刺激肠道运动。ML10302通过激活胆碱能通路,在小肠和结肠中诱导显著的运动前收缩。ML 10302还具有研究神经病学疾病的潜力【1】。 |
| 英文名 | 2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate |
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| 英文别名 | 更多 |
| 描述 | ML 10302是一种有效的激动剂5-HT4受体,Ki为1.07 nM。5-羟色胺(5-HT4)受体激动剂通过胆碱能途径刺激肠道运动。ML10302通过激活胆碱能通路,在小肠和结肠中诱导显著的运动前收缩。ML 10302还具有研究神经病学疾病的潜力【1】。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.223g/cm3 |
|---|---|
| 沸点 | 472.7ºC at 760 mmHg |
| 分子式 | C15H21ClN2O3 |
| 分子量 | 312.79200 |
| 闪点 | 239.7ºC |
| 精确质量 | 312.12400 |
| PSA | 64.79000 |
| LogP | 3.09260 |
| 蒸汽压 | 4.18E-09mmHg at 25°C |
| 折射率 | 1.563 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 危险品运输编码 | NONH for all modes of transport |
| 海关编码 | 2933399090 |
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~52%
2-piperidin-1-y... 148868-55-7 |
| 文献：Elz; Keller Archiv der Pharmazie, 1995 , vol. 328, # 7-8 p. 585 - 594 |
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~%
2-piperidin-1-y... 148868-55-7 |
| 文献：Yang, Donglai; Soulier, Jean-Louis; Sicsic, Sames; Mathe-Allainmat, Monique; Bremont, Beatrice; Croci, Tiziano; Cardamone, Rosanna; Aureggi, Giulio; Langlois, Michel Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 608 - 621 |
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~%
2-piperidin-1-y... 148868-55-7 |
| 文献：Yang, Donglai; Soulier, Jean-Louis; Sicsic, Sames; Mathe-Allainmat, Monique; Bremont, Beatrice; Croci, Tiziano; Cardamone, Rosanna; Aureggi, Giulio; Langlois, Michel Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 608 - 621 |
| 海关编码 | 2933399090 |
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| 中文概述 | 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies.
J. Med. Chem. 48 , 6220-6228, (2005) Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception ... |
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New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
J. Med. Chem. 40 , 608-621, (1997) A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimul... |
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Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon.
Neurogastroenterol. Motil. 13 , 543-553, (2001) 5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also... |
| 2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate |
