2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate

更新时间：2024-01-09 09:33:04

2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate结构式	常用名	2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate	英文名	2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate
	CAS号	148868-55-7	分子量	312.79200
	密度	1.223g/cm3	沸点	472.7ºC at 760 mmHg
	分子式	C₁₅H₂₁ClN₂O₃	熔点	N/A
	MSDS	中文版美版	闪点	239.7ºC

用途

ML 10302是一种有效的激动剂5-HT4受体,Ki为1.07 nM。5-羟色胺(5-HT4)受体激动剂通过胆碱能途径刺激肠道运动。ML10302通过激活胆碱能通路,在小肠和结肠中诱导显著的运动前收缩。ML 10302还具有研究神经病学疾病的潜力【1】。

英文名	2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate
英文别名	更多

描述	ML 10302是一种有效的激动剂5-HT4受体,Ki为1.07 nM。5-羟色胺(5-HT4)受体激动剂通过胆碱能途径刺激肠道运动。ML10302通过激活胆碱能通路,在小肠和结肠中诱导显著的运动前收缩。ML 10302还具有研究神经病学疾病的潜力【1】。
相关类别	研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体
参考文献	[1]. Cachard-Chastel M, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007;150(7):883-892. [2]. Yang D, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997;40(4):608-621. [3]. De Ponti F, et al. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001;13(6):543-553.

描述

相关类别

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

参考文献

[1]. Cachard-Chastel M, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007;150(7):883-892.

[2]. Yang D, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997;40(4):608-621.

[3]. De Ponti F, et al. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001;13(6):543-553.

密度	1.223g/cm3
沸点	472.7ºC at 760 mmHg
分子式	C₁₅H₂₁ClN₂O₃
分子量	312.79200
闪点	239.7ºC
精确质量	312.12400
PSA	64.79000
LogP	3.09260
蒸汽压	4.18E-09mmHg at 25°C
折射率	1.563

MSDS英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
海关编码	2933399090

1-(2-氯乙基)哌啶

1932-03-2

4-氨基-5-氯-2-甲氧基苯甲酸

7206-70-4

~52%

2-piperidin-1-y...

148868-55-7

文献：Elz; Keller Archiv der Pharmazie, 1995 , vol. 328, # 7-8 p. 585 - 594

4-氨基-5-氯-2-甲氧基苯甲酸

7206-70-4

2-piperidin-1-y...

148868-55-7

文献：Yang, Donglai; Soulier, Jean-Louis; Sicsic, Sames; Mathe-Allainmat, Monique; Bremont, Beatrice; Croci, Tiziano; Cardamone, Rosanna; Aureggi, Giulio; Langlois, Michel Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 608 - 621

六氢吡啶

110-89-4

4-amino-5-chlor...

172679-60-6

2-piperidin-1-y...

148868-55-7

上游产品 3
CAS号1932-03-2 1-(2-氯乙基)哌啶 CAS号7206-70-4 4-氨基-5-氯-2-甲氧基苯甲酸 CAS号110-89-4 六氢吡啶
下游产品 0

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies.

J. Med. Chem. 48 , 6220-6228, (2005)

Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception ...

New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.

J. Med. Chem. 40 , 608-621, (1997)

A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimul...

Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon.

Neurogastroenterol. Motil. 13 , 543-553, (2001)

5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also...

2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate