L 691816

• 常用名: L 691816
• 英文名: L 691816
• CAS号: 150461-07-7
• 分子量: 635.22
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₆H₃₅ClN₆OS
• 熔点: N/A
• 闪点: N/A

L 691816用途

L 691816是一种强效、选择性和口服活性的5-脂氧合酶抑制剂。L 691816可用于过敏和哮喘的研究[1]。

L 691816名称

• 英文名: L 691816

L 691816生物活性

• 描述: L 691816是一种强效、选择性和口服活性的5-脂氧合酶抑制剂。L 691816可用于过敏和哮喘的研究[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
• 参考文献:

  [1]. Hutchinson JH, et, al. Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. J Med Chem. 1993 Sep 17;36(19):2771-87.

L 691816物理化学性质

• 分子式: C₃₆H₃₅ClN₆OS
• 分子量: 635.22
• InChIKey: ZXTQNTHPGKKAHX-UHFFFAOYSA-N
• SMILES: CC1Cc2c(OCc3ccc(-c4ccccc4)cn3)ccc3c2c(c(CC(C)(C)Cc2nn[nH]n2)n3Cc2ccc(Cl)cc2)S1

L 691816靶点实验

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实验名称：Tested for inhibition against ram seminal vesicle Prostaglandin G/H synthase at a con... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL763249

实验名称：Maximum time taken for compound to reach peak concentration in rat plasma 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL875769

实验名称：In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN... 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL619246

实验名称：Tested for effective inhibition of LTB4 with an 8 hr pretreatment 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL781494

实验名称：Peak concentration in rat plasma was determined 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL623792

实验名称：Rate of enzyme inactivation for the compound was determined 来源：ChEMBL 靶标：N/A External Id：CHEMBL628161

实验名称：Bioavailability in rat (dose 20 mg/kg p.o. in 1% methocel, and 5 mg/kg i.v. in PEG400... 来源：ChEMBL 靶标：N/A External Id：CHEMBL625391

实验名称：Changes in airway resistance after administration of 0.3 mg/kg in squirrel monkey 来源：ChEMBL 靶标：Cercopithecidae External Id：CHEMBL730647

实验名称：Tested for inhibition of leukotriene B4 in rat pleurisy model (8 hours pretreatment) 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL781501

实验名称：Changes in airway resistance after administration of 1 mg/kg in squirrel monkey 来源：ChEMBL 靶标：Cercopithecidae External Id：CHEMBL730648

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