盐酸诺拉曲塞

• 常用名: 盐酸诺拉曲塞
• 英文名: Nolatrexed dihydrochloride
• CAS号: 152946-68-4
• 分子量: 357.258
• 密度: N/A
• 沸点: 493.6ºCat 760 mmHg
• 分子式: C₁₄H₁₄Cl₂N₄OS
• 熔点: 301-302ºC
• 闪点: 252.3ºC

盐酸诺拉曲塞用途

Nolatrexed dihydrochloride (AG 337) 是一种非竞争性的胸苷酸合酶 (thymidylate synthase) 抑制剂,与该酶的叶酸辅因子结合位点相互作用,对人 thymidylate synthase 的 Ki 值为 11 nM。Nolatrexed dihydrochloride (AG 337) 具有抗癌作用,能够在癌细胞 S 期诱导细胞周期停滞。

盐酸诺拉曲塞名称

• 中文名: 盐酸诺拉曲塞
• 英文名: 2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one,dihydrochloride
• 中文别名: 2-氨基-6-甲基-5-(4-吡啶巯基)-4(1H)-喹唑啉酮二盐酸盐 | 盐酸诺拉曲噻

盐酸诺拉曲塞生物活性

• 描述: Nolatrexed dihydrochloride (AG 337) 是一种非竞争性的胸苷酸合酶 (thymidylate synthase) 抑制剂,与该酶的叶酸辅因子结合位点相互作用,对人 thymidylate synthase 的 Ki 值为 11 nM。Nolatrexed dihydrochloride (AG 337) 具有抗癌作用,能够在癌细胞 S 期诱导细胞周期停滞。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 胸苷酸合成酶
  研究领域 >> 癌症
• 靶点实验:

  Ki: 11 nM (Human Thymidylate Synthase)[1]

• 参考文献:

  [1]. Webber S, et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17.

  [2]. McGuire JJ, et al. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.

盐酸诺拉曲塞物理化学性质

• 沸点: 493.6ºCat 760 mmHg
• 熔点: 301-302ºC
• 分子式: C₁₄H₁₄Cl₂N₄OS
• 分子量: 357.258
• 闪点: 252.3ºC
• 精确质量: 356.026550
• PSA: 109.96000
• LogP: 4.54510
• 外观性状: 黄褐色固体
• 储存条件: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• 稳定性: Hygroscopic

盐酸诺拉曲塞靶点实验

查看更多实验

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实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS233

实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ... 来源：824 靶标：N/A External Id：P53MS837

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS898

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

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盐酸诺拉曲塞英文别名

• 2-Amino-6-methyl-5-(4-pyridinylsulfanyl)-4(1H)-quinazolinone dihydrochloride
• Thymitaq
• 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)quinazolin-4(3H)-one dihydrochloride
• MFCD00917041
• 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, hydrochloride (1:2)
• Nolatrexed dihydrochloride
• AG 337