LY 292728

• 常用名: LY 292728
• 英文名: LY 292728
• CAS号: 153034-77-6
• 分子量: 600.58700
• 密度: 1.376g/cm3
• 沸点: 836.6ºC at 760 mmHg
• 分子式: C₃₄H₂₉FO₉
• 熔点: N/A
• 闪点: 459.8ºC

LY 292728用途

LY 292728 是一种有效的白三烯 B4 (LTB4) 受体拮抗剂。LY 292728 与人中性粒细胞结合的 Ki 为 0.47 nM,与豚鼠肺膜结合的 Ki 为 0.04 nM。

LY 292728名称

• 英文名: 5-(2-carboxyethyl)-6-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-9-oxoxanthene-2-carboxylic acid

LY 292728生物活性

• 描述: LY 292728 是一种有效的白三烯 B4 (LTB4) 受体拮抗剂。LY 292728 与人中性粒细胞结合的 Ki 为 0.47 nM,与豚鼠肺膜结合的 Ki 为 0.04 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 白三烯受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Sawyer JS, et al. Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4.

LY 292728物理化学性质

• 密度: 1.376g/cm3
• 沸点: 836.6ºC at 760 mmHg
• 分子式: C₃₄H₂₉FO₉
• 分子量: 600.58700
• 闪点: 459.8ºC
• 精确质量: 600.18000
• PSA: 143.50000
• LogP: 6.58360
• InChIKey: DCTKEJXAVFAMFK-UHFFFAOYSA-N
• SMILES: CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O
• 蒸汽压: 1.07E-29mmHg at 25°C
• 折射率: 1.636

LY 292728靶点实验

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实验名称：LTB4 receptor antagonist activity was determined by inhibition of specific binding of... 来源：ChEMBL 靶标：Leukotriene B4 receptor 1 External Id：CHEMBL709168

实验名称：Compound was tested for Leukotriene B4-mediated Up-regulation of human neutrophil CD1... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL700865

实验名称：Inhibition of LTB4-induced up-regulation of human neutrophil CD11b/CD18 integrin 来源：ChEMBL 靶标：Leukotriene B4 receptor 2 External Id：CHEMBL751445

实验名称：Inhibition of LTB4 induced expression of human neutrophil integrin CD11b/CD18. 来源：ChEMBL 靶标：Leukotriene B4 receptor 2 External Id：CHEMBL699620

实验名称：Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing ... 来源：ChEMBL 靶标：Leukotriene B4 receptor 1 External Id：CHEMBL706760

实验名称：Binding affinity towards Leukotriene B4 receptor guinea pig lung membrane using [3H]L... 来源：ChEMBL 靶标：Leukotriene B4 receptor 2 External Id：CHEMBL704379

实验名称：LTB4 receptor antagonist activity was determined by inhibition of specific binding of... 来源：ChEMBL 靶标：Leukotriene B4 receptor 1 External Id：CHEMBL711830

实验名称：Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [... 来源：ChEMBL 靶标：Leukotriene B4 receptor 1 External Id：CHEMBL709859

实验名称：Compound was tested in vitro inhibitory activity against human neutrophil CD11b/CD18.... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL699805

实验名称：Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes ex... 来源：ChEMBL 靶标：Leukotriene B4 receptor 1 External Id：CHEMBL705025

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LY 292728英文别名

• 9h-xanthene-4-propanoic acid,7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-9-oxo