ML355

• 常用名: ML355
• 英文名: ML355
• CAS号: 1532593-30-8
• 分子量: 441.523
• 密度: 1.5±0.1 g/cm3
• 沸点: 654.5±65.0 °C at 760 mmHg
• 分子式: C₂₁H₁₉N₃O₄S₂
• 熔点: N/A
• 闪点: 349.6±34.3 °C

ML355用途

ML355是一高效、选择性12-LOX抑制剂，IC50值为0.34uM，对其他脂氧化酶和环氧化酶有很好的选择性，具有较好的药物动力学特征。

ML355名称

• 中文名: ML355
• 英文名: ML355

ML355生物活性

• 描述: ML355是一高效、选择性12-LOX抑制剂,IC50值为0.34uM,对其他脂氧化酶和环氧化酶有很好的选择性,具有较好的药物动力学特征。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Luci DK, et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506.

  [2]. Zhang XJ, et al. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. Nat Med. 2018 Jan;24(1):73-83.

ML355物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 654.5±65.0 °C at 760 mmHg
• 分子式: C₂₁H₁₉N₃O₄S₂
• 分子量: 441.523
• 闪点: 349.6±34.3 °C
• 精确质量: 441.081696
• LogP: 3.95
• InChIKey: OWHBVKBNNRYMIN-UHFFFAOYSA-N
• SMILES: COc1cccc(CNc2ccc(S(=O)(=O)Nc3nc4ccccc4s3)cc2)c1O
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.725
• 储存条件: 2-8℃

ML355靶点实验

查看更多实验

实验名称：Inhibition of 12-LOX in washed human platelets assessed as inhibition of PAR4-AP-indu... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12 External Id：CHEMBL3118872

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Inhibition of 12-LOX in washed human platelets assessed as inhibition of PAR4-AP-indu... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12 External Id：CHEMBL3118873

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Thermal Shift Assay. Domain start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4650107

实验名称：Mixed-type inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidon... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12 External Id：CHEMBL3118874

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Inhibition of N-terminal His6-tagged human platelet 12-LOX assessed as degradation of... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12 External Id：CHEMBL3118877

实验名称：Stability of the compound in PBS buffer at pH 7.4 measured at 48 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL3118878

实验名称：Metabolic stability in mouse plasma assessed as compound remaining measured at 2 hrs 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3118879

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ML355英文别名

• ML355
• N-(1,3-Benzothiazol-2-yl)-4-[(2-hydroxy-3-methoxybenzyl)amino]benzenesulfonamide