4,6-二氯-3-[(1e)-3-氧代-3-(苯氨基)-1-丙基]-1h-吲哚-2-羧酸钠

• 常用名: 4,6-二氯-3-[(1e)-3-氧代-3-(苯氨基)-1-丙基]-1h-吲哚-2-羧酸钠
• 英文名: Gavestinel
• CAS号: 153436-22-7
• 分子量: 375.21
• 密度: 1.561g/cm3
• 沸点: 701.1ºC at 760mmHg
• 分子式: C₁₈H₁₂Cl₂N₂O₃
• 熔点: N/A
• 闪点: 377.8ºC

用途

Gavestinel(GV 150526)是NMDA受体拮抗剂的甘氨酸位点的选择性和有效性。加维司汀具有神经保护作用[1]。

名称

• 中文名: 4,6-二氯-3-[(1e)-3-氧代-3-(苯氨基)-1-丙基]-1h-吲哚-2-羧酸钠
• 英文名: 3-[(E)-3-anilino-3-oxoprop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylic acid

生物活性

• 描述: Gavestinel(GV 150526)是NMDA受体拮抗剂的甘氨酸位点的选择性和有效性。加维司汀具有神经保护作用[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 参考文献:

  [1]. J F Hoke, et al. Pharmacokinetics of a glycine site antagonist (gavestinel) following multiple dosing in patients with acute stroke. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):867-72.

物理化学性质

• 密度: 1.561g/cm3
• 沸点: 701.1ºC at 760mmHg
• 分子式: C₁₈H₁₂Cl₂N₂O₃
• 分子量: 375.21
• 闪点: 377.8ºC
• 精确质量: 396.00400
• PSA: 85.02000
• LogP: 3.56310
• InChIKey: WZBNEZWCNKUOSM-VOTSOKGWSA-N
• SMILES: O=C(C=Cc1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)Nc1ccccc1
• 蒸汽压: 1.24E-20mmHg at 25°C

靶点实验

查看更多实验

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英文别名

• Gavestinel