GTS-21二盐酸盐(DMBX-A)结构式
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常用名 | GTS-21二盐酸盐(DMBX-A) | 英文名 | GTS-21 |
|---|---|---|---|---|
| CAS号 | 156223-05-1 | 分子量 | 381.30 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 485.6±45.0 °C at 760 mmHg | |
| 分子式 | C19H22Cl2N2O2 | 熔点 | 216-217℃ (decomposition) | |
| MSDS | 美版 | 闪点 | 247.5±28.7 °C |
GTS-21二盐酸盐(DMBX-A)用途GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。 |
| 中文名 | (1:2),(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3-联吡啶盐酸盐 |
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| 英文名 | 3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl |
| 中文别名 | (3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 |
| 英文别名 | 更多 |
| 描述 | GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 485.6±45.0 °C at 760 mmHg |
| 熔点 | 216-217℃ (decomposition) |
| 分子式 | C19H22Cl2N2O2 |
| 分子量 | 381.30 |
| 闪点 | 247.5±28.7 °C |
| PSA | 43.71000 |
| LogP | 2.64 |
| 外观性状 | powder,faint yellow to dark yellow |
| 蒸汽压 | 0.0±1.2 mmHg at 25°C |
| 折射率 | 1.580 |
| 储存条件 | 2-8°C |
| 水溶解性 | H2O: >5mg/mL |
| 危险品运输编码 | NONH for all modes of transport |
|---|---|
| WGK德国 | 3 |
| RTECS号 | DW1764860 |
| 海关编码 | 2933399090 |
| 海关编码 | 2933399090 |
|---|---|
| 中文概述 | 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Central muscarinic cholinergic activation alters interaction between splenic dendritic cell and CD4+CD25- T cells in experimental colitis.
PLoS ONE 9(10) , e109272, (2014) The cholinergic anti-inflammatory pathway (CAP) is based on vagus nerve (VN) activity that regulates macrophage and dendritic cell responses in the spleen through alpha-7 nicotinic acetylcholine recep... |
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Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Br. J. Pharmacol. 172 , 5123-35, (2015) α7 nicotinic acetylcholine receptors (α7 nAChRs) may represent useful targets for cognitive improvement. The aim of this study is to compare the pro-cognitive activity of selective α7-nAChR ligands, i... |
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The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia.
J. Neuroimmunol. 251(1-2) , 65-72, (2012) The anti-inflammatory properties of, particularly the α7, nicotinic acetylcholine receptors (nAChRs) in the peripheral immune system are well documented. There are also reports of anti-inflammatory ac... |
| 3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl |
| 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride |
| 3-(2,4-dimethoxybenzylidene)anabaseine |
| 2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, (3E)- |
| 3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3'-bipyridine |
| (3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine |
| 3-(2,4)-DiMethoxybenzylidineanabaseine |
| GTS-21 |
| DMXB-A |
| GTS 21 2HCl |
| GTS-21 (dihydrochloride) |
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