G244-LM

• 常用名: G244-LM
• 英文名: G244-LM
• CAS号: 1563007-08-8
• 分子量: 406.522
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₂₂N₄O₃S₂
• 熔点: N/A
• 闪点: N/A

G244-LM用途

G244-LM是抑制Wnt信号传导的tankyrase 1/2的有效和特异性抑制剂[1]。

G244-LM名称

• 英文名: 2-{4-[2-(Methylsulfonyl)phenyl]-1-piperazinyl}-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one

G244-LM生物活性

• 描述: G244-LM是抑制Wnt信号传导的tankyrase 1/2的有效和特异性抑制剂[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> PARP
  信号通路 >> 细胞周期/DNA损伤 >> PARP
• 参考文献:

  [1]. Lau T, et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res. 2013 May 15;73(10):3132-44.

G244-LM物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₈H₂₂N₄O₃S₂
• 分子量: 406.522
• 精确质量: 406.113342
• LogP: 0.04
• InChIKey: JSQPAEVPPSCQMV-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)c1ccccc1N1CCN(c2nc3c(c(=O)[nH]2)CSCC3)CC1
• 折射率: 1.727
• 储存条件: -20°C，避光，干燥，密封

G244-LM安全信息

• 危害码 (欧洲): Xi

G244-LM靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

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G244-LM英文别名

• 2-{4-[2-(Methylsulfonyl)phenyl]-1-piperazinyl}-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one
• G244-LM