RLH-033

• 常用名: RLH-033
• 英文名: RLH-033
• CAS号: 157097-10-4
• 分子量: 458.97800
• 密度: N/A
• 沸点: 571.5ºC at 760 mmHg
• 分子式: C₂₅H₃₁ClN₂O₄
• 熔点: N/A
• 闪点: 299.4ºC

RLH-033用途

RLH-033 是 sigma 1 识别位点的有效选择性配体。RLH-033 对 [3H](+)-pentazocine 标记的 sigma 1 位点具有高亲和力,Ki 为 50 pM。

RLH-033名称

• 英文名: 2-(4-phenylpiperidin-1-yl)ethyl 1-(4-nitrophenyl)cyclopentane-1-carboxylate,hydrochloride

RLH-033生物活性

• 描述: RLH-033 是 sigma 1 识别位点的有效选择性配体。RLH-033 对 [3H](+)-pentazocine 标记的 sigma 1 位点具有高亲和力,Ki 为 50 pM。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. R L Hudkins, et al. RLH-033, a novel, potent and selective ligand for the sigma 1 recognition site. Eur J Pharmacol. 1994 Dec 12;271(1):235-6.

RLH-033物理化学性质

• 沸点: 571.5ºC at 760 mmHg
• 分子式: C₂₅H₃₁ClN₂O₄
• 分子量: 458.97800
• 闪点: 299.4ºC
• 精确质量: 458.19700
• PSA: 75.36000
• LogP: 6.09250
• InChIKey: RQQAHFSSIAWEPI-UHFFFAOYSA-N
• SMILES: Cl.O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1
• 蒸汽压: 4.54E-13mmHg at 25°C

RLH-033靶点实验

查看更多实验

实验名称：Binding affinity was measured as selectivity for sigma-1 site over N-methyl-D-asparta... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 3A External Id：CHEMBL748074

实验名称：Binding affinity was measured as selectivity for sigma-1 site over opioid receptor in... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL756533

实验名称：Affinity at sigma-1 site by inhibition of [3H](+)-pentazocine (PENT) binding in guine... 来源：ChEMBL 靶标：Sigma non-opioid intracellular receptor 1 External Id：CHEMBL801234

实验名称：The compound was evaluated for affinity at sigma-2 site by inhibition of [3H]1,3-di(2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL805220

实验名称：Binding affinity was measured as selectivity for sigma-1 site over phencyclidine (PCP... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 3A External Id：CHEMBL764635

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RLH-033英文别名

• 2-(4-phenylpiperidin-1-yl)ethyl 1-(4-nitrophenyl)cyclopentane-1-carboxylate hydrochloride
• 2-(4-Phenylpiperidinyl)ethyl 1-(4-nitrophenyl)cyclopentanecarboxylate hydrochloride
• Rlh 033