COX-2-IN-16

• 常用名: COX-2-IN-16
• 英文名: COX-2-IN-16
• CAS号: 1610894-92-2
• 分子量: 394.22
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₂BrN₃O₂
• 熔点: N/A
• 闪点: N/A

COX-2-IN-16用途

COX-2-IN-16(化合物2b)是一种有效、选择性和口服活性的COX-2抑制剂,IC50为102µM。COX-2-IN-16抑制NO的生成。COX-2-IN-16具有抗炎活性[1]。

COX-2-IN-16名称

• 英文名: COX-2-IN-16

COX-2-IN-16生物活性

• 描述: COX-2-IN-16(化合物2b)是一种有效、选择性和口服活性的COX-2抑制剂,IC50为102µM。COX-2-IN-16抑制NO的生成。COX-2-IN-16具有抗炎活性[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 靶点实验:

  COX-2:102 μM (IC50)

• 体内研究: COX-2-IN-16(化合物2b)(100 mg/kg；p.o.)显示,在大鼠足肿胀模型中,水肿形成减少了42%。
• 参考文献:

  [1]. García-Aranda MI, et al. Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore. Bioorg Med Chem. 2020 May 1;28(9):115427.

COX-2-IN-16物理化学性质

• 分子式: C₁₉H₁₂BrN₃O₂
• 分子量: 394.22

COX-2-IN-16靶点实验

查看更多实验

实验名称：Inhibition of bovine COX1 at 100 uM using arachidonic acid as substrate preincubated ... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL4629019

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 100 uM measur... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4629018

实验名称：Selectivity index, ratio of inhibition of human recombinant COX-2 at 100 uM to inhibi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4629021

实验名称：Inhibition of human recombinant COX-2 at 100 uM using arachidonic acid as substrate p... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 2 External Id：CHEMBL4629020

实验名称：Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubate... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 2 External Id：CHEMBL4629022

实验名称：Inhibition of iNOS in mouse macrophages assessed as reduction in LPS-induced nitric o... 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL4629025

实验名称：Inhibition of iNOS in mouse macrophages assessed as reduction in LPS-induced nitric o... 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL4629024

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4629027

实验名称：Antiinflammatory activity in Wistar rat assessed as inhibition of carrageenan-induced... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4629026

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