ARN-3236

• 常用名: ARN-3236
• 英文名: ARN-3236
• CAS号: 1613710-01-2
• 分子量: 336.41
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆N₂O₂S
• 熔点: N/A
• 闪点: N/A

ARN-3236用途

ARN-3236 是具有口服活性的盐诱导激酶2 (SIK2) (IC50 <1 nM) 的选择性抑制剂,具有抑制体内外卵巢癌细胞生长以及增加癌细胞对紫杉醇敏感度的活性。

ARN-3236名称

• 中文名: ARN-3236
• 英文名: ARN-3236

ARN-3236生物活性

• 描述: ARN-3236 是具有口服活性的盐诱导激酶2 (SIK2) (IC50 <1 nM) 的选择性抑制剂,具有抑制体内外卵巢癌细胞生长以及增加癌细胞对紫杉醇敏感度的活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> 盐诱导激酶(SIK)
• 靶点实验:

  SIK2:<1 nM (IC50)

  SIK1:21.63 nM (IC50)

  SIK3:6.63 nM (IC50)

• 参考文献:

  [1]. Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99(5):711-21.

  [2]. Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954.

ARN-3236物理化学性质

• 分子式: C₁₉H₁₆N₂O₂S
• 分子量: 336.41
• InChIKey: WEHOIIGXTMKVRG-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2c[nH]c3nccc(-c4ccsc4)c23)c(OC)c1
• 储存条件: 2-8℃

ARN-3236靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGF... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL5303712

实验名称：Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513083

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Inhibition of LCK (unknown origin) at 0.5 uM 来源：ChEMBL 靶标：Tyrosine-protein kinase Lck External Id：CHEMBL5151354

实验名称：Inhibition of NUAK2 (unknown origin) at 0.5 uM 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 2 External Id：CHEMBL5151355

实验名称：Inhibition of VGFR2 (unknown origin) at 0.5 uM 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL5151356

实验名称：Inhibition of SRPK1 (unknown origin) at 0.5 uM 来源：ChEMBL 靶标：SRSF protein kinase 1 External Id：CHEMBL5151357

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibition of JAK2 (unknown origin) at 0.5 uM 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL5151353

实验名称：Inhibition of SIK2 (unknown origin) 来源：ChEMBL 靶标：Serine/threonine-protein kinase SIK2 External Id：CHEMBL5371426

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ARN-3236英文别名

• 3-(2,4-DIMETHOXYPHENYL)-4-(THIOPHEN-3-YL)-1H-PYRROLO[2,3-B]PYRIDINE