CDP 840 hydrochloride

• 常用名: CDP 840 hydrochloride
• 英文名: CDP 840 hydrochloride
• CAS号: 162542-90-7
• 分子量: 373.49
• 密度: 1.122g/cm3
• 沸点: 489.9ºC at 760 mmHg
• 分子式: C₂₅H₂₇NO₂
• 熔点: N/A
• 闪点: 174.3ºC

CDP 840 hydrochloride用途

CDP-840(GR259653X)是一种高效、选择性和口服活性磷酸二酯酶IV(PDE IV)抑制剂。CDP-840抑制抗原诱导的清醒松鼠猴早期和晚期支气管收缩[1]。

CDP 840 hydrochloride名称

• 英文名: 4-[2-(3-cyclopentyloxy-4-methoxyphenyl)-2-phenylethyl]pyridine

CDP 840 hydrochloride生物活性

• 描述: CDP-840(GR259653X)是一种高效、选择性和口服活性磷酸二酯酶IV(PDE IV)抑制剂。CDP-840抑制抗原诱导的清醒松鼠猴早期和晚期支气管收缩[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
• 靶点实验:

  PDE4

• 参考文献:

  [1]. Jones TR, et al. Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma. Can J Physiol Pharmacol. 1998 Feb;76(2):210-7.

CDP 840 hydrochloride物理化学性质

• 密度: 1.122g/cm3
• 沸点: 489.9ºC at 760 mmHg
• 分子式: C₂₅H₂₇NO₂
• 分子量: 373.49
• 闪点: 174.3ºC
• 精确质量: 373.20400
• PSA: 31.35000
• LogP: 5.78620
• InChIKey: UTUUPXBCDMQYRR-HSZRJFAPSA-N
• SMILES: COc1ccc(C(Cc2ccncc2)c2ccccc2)cc1OC1CCCC1
• 蒸汽压: 2.88E-09mmHg at 25°C
• 折射率: 1.591

CDP 840 hydrochloride靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of ozone-induced hyperactivity to histamine in guinea pigs on intraperiton... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL689530

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Increased pulmonary inflation pressure causing bronchoconstriction in ovalbumin sensi... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685596

实验名称：Reduction of antigen-induced pulmonary eosinophilia in sensitized guinea pigs 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685595

实验名称：Inhibition of N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated production of... 来源：ChEMBL 靶标：N/A External Id：CHEMBL761981

实验名称：Inhibition of guinea pig macrophage Phosphodiesterase 4 来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4A External Id：CHEMBL767081

实验名称：Half life of compound was determined in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL627711

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