YM-90709

更新时间：2025-08-23 01:09:28

YM-90709结构式	常用名	YM-90709	英文名	YM-90709
	CAS号	163769-88-8	分子量	359.421
	密度	1.3±0.1 g/cm3	沸点	579.6±50.0 °C at 760 mmHg
	分子式	C₂₂H₂₁N₃O₂	熔点	N/A
	MSDS	N/A	闪点	304.3±30.1 °C

YM-90709用途

YM-90709是一种新型拮抗剂, 抑制IL-5与IL-5受体结合。

中文名	5,6-二氢-2,3-二甲氧基-6,6-二甲基苯并[7,8]吲哚烷并[2,3-b]喹噁啉
英文名	ym 90709
英文别名	更多

描述	YM-90709是一种新型拮抗剂, 抑制IL-5与IL-5受体结合。
相关类别	信号通路 >> 免疫及炎症 >> 白细胞介素相关研究领域 >> 炎症/免疫
参考文献	[1]. Morokata T, et al. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol. 2002 Nov;2(12):1693-702. [2]. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5. [3]. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int Immunopharmacol. 2004 Jul;4(7):873-83.

描述

YM-90709是一种新型拮抗剂, 抑制IL-5与IL-5受体结合。

相关类别

信号通路 >> 免疫及炎症 >> 白细胞介素相关

研究领域 >> 炎症/免疫

参考文献

[1]. Morokata T, et al. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol. 2002 Nov;2(12):1693-702.

[2]. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5.

[3]. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int Immunopharmacol. 2004 Jul;4(7):873-83.

密度	1.3±0.1 g/cm3
沸点	579.6±50.0 °C at 760 mmHg
分子式	C₂₂H₂₁N₃O₂
分子量	359.421
闪点	304.3±30.1 °C
精确质量	359.163391
PSA	49.17000
LogP	5.89
InChIKey	HIXSPVQXXDULHS-UHFFFAOYSA-N
SMILES	COc1cc2c(cc1OC)-c1cc3nc4ccccc4nc3n1C(C)(C)C2
外观性状	粉末
蒸汽压	0.0±1.5 mmHg at 25°C
折射率	1.666
储存条件	-20℃

海关编码	2933990090

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
来源：NCGC
靶标：N/A
External Id：SERCaMPGLuc-p1-antagonist

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E...
来源：NCGC
External Id：epac1-activator-v

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3...
来源：NCGC
External Id：epac1-inhibitor-v

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (E...
来源：NCGC
External Id：epac2-activator-v2

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4...
来源：NCGC
External Id：epac2-inhibitor-v2

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4513082

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
来源：NCGC
靶标：TDP1 protein [Homo sapiens]
External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
来源：NCGC
靶标：TDP1 protein [Homo sapiens]
External Id：TDP1101

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：N/A
External Id：HMS1315

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Tocris-1675

2,3-Dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline

Bio-0867

YM-90709