FPPQ

• 常用名: FPPQ
• 英文名: FPPQ
• CAS号: 1648745-46-3
• 分子量: 410.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₉FN₄O₂S
• 熔点: N/A
• 闪点: N/A

FPPQ用途

FPPQ是一种双作用的5-HT3(Ki=0.9nm)和5-HT6(Ki=3nm)受体拮抗剂,具有抗精神病和促认知特性。

FPPQ名称

• 英文名: FPPQ

FPPQ生物活性

• 描述: FPPQ是一种双作用的5-HT3(Ki=0.9nm)和5-HT6(Ki=3nm)受体拮抗剂,具有抗精神病和促认知特性。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Zajdel P, et al. Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties. J Med Chem. 2021 Sep 23;64(18):13279-13298.

FPPQ物理化学性质

• 分子式: C₂₁H₁₉FN₄O₂S
• 分子量: 410.46

FPPQ靶点实验

查看更多实验

实验名称：Chemical stability of compound at pH 1.2 to 8 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844563

实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844562

实验名称：Antagonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as inh... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 6 External Id：CHEMBL4844530

实验名称：Antagonist activity at GFP-tagged 5-HT6 receptor (unknown origin) expressed in NG108-... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 6 External Id：CHEMBL4844561

实验名称：Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes ... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 6 External Id：CHEMBL4844529

实验名称：Pro-cognitive activity in po dosed Sprague-Dawley rat assessed as prevention of PCP-i... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4844592

实验名称：Metabolic stability in pooled human liver microsomes assessed as intrinsic clearance ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844565

实验名称：Aqueous solubility of compound at pH 7 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844564

实验名称：Metabolic stability in pooled rat liver microsomes assessed as intrinsic clearance at... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844532

实验名称：Binding affinity to human 5-HT2B receptor at 1 uM relative to control 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B External Id：CHEMBL4844559

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